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载荷对椎间盘退变影响的在体动物实验模型研究进展

Loading device in animal model for study of mechanism of intervertebral disc degeneration
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摘要 载荷与椎间盘退变之间的关系是研究椎间盘退变机制具的关键点,而设计制造合适的加载装置在动物体内进行加载实验对深入研究和探索载荷与椎间盘退变之间的关系十分重要。本文综述了国内外利用活体实验动物研探索载荷对椎间盘影响的研究,并且评价了各种在体动物模型的特点和优缺点,可以为研究载荷与椎间盘退变关系的研究者在动物模型的选择上提供一定的参考和帮助。 Compression loading may induce intervertebral disc degeneration（ IDD）, and the development of a proper loading device in animal model is essential for study of the mechanism of IDD. This article will describe a variety of loading devices used in different animal models in vivo,and discuss their characteristics and advantages.
作者 夏冬冬 谭军
机构地区 同济大学附属东方医院脊柱外科
出处 《同济大学学报（医学版）》 CAS 2016年第1期115-119,共5页 Journal of Tongji University(Medical Science)
基金 上海市浦东新区学科带头人计划(PWRd-2011-02)
关键词 载荷 加载装置 椎间盘退变 动物实验 loading loading device intervertebral disc degeneration animal experiment
分类号 R681.53 [医药卫生—骨科学]
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参考文献28

  • 1Adams MA, Roughley PJ. What is intervertebral disc degeneration, and what causes it? [J]. Spine ( Phila Pa 1976) ,2006,31(18) : 2151 -2161.
  • 2Walsh AJ, Lotz JC. Biological response of the intervertebral disc to dynamic loading[J]. J Biomech, 2004,37(3) : 329 -337.
  • 3Iatridis JC, Mente PL, Stokes IA, et al. Compression- induced changes in intervertebral disc properties in a rat tail model[ J]. Spine ( Phila Pa 1976), 1999,24 (10) : 996 - 1002.
  • 4Yurube T, Takada T, Hirata H, et al. Modified house- keeping gene expression in a rat tail compression loading-induced disc degeneration model[ J ]. J Orthop Res, 2011,29(8) : 1284 - 1290.
  • 5Yurube T, Nishida K, Suzuki T, et al. Matrix metalloproteinase (MMP) -3 gene up-regulation in a rat tail compression loading-induced disc degeneration model[J]. J Orthop Res, 2010,28(8) : 1026- 1032.
  • 6Lai A, Chow DH, Siu SW, et al. Effects of static compression with different loading magnitudes and durations on the intervertebral disc: an in vivo rat-tail study [ J ]. Spine ( Phila Pa 1976 ), 2008,33 ( 25 ) : 2721 -2727.
  • 7MacLean J J, Lee CR, Grad S, et al. Effects of immobilization and dynamic compression on intervertebral disc cell gene expression in vivo [ J ]. Spine (Phila Pa 1976),2003,28( 10): 973-981.
  • 8Wuertz K, Godburn K, MacLean J], et al. In vivo remodeling of intervertebral discs in response to short- and long-term dynamic compression [J]. J Orthop Res, 2009,27(9) : 1235 - 1242.
  • 9Ching CT, Chow DH, Yao FY, et al. Changes in nuclear composition following cyclic compression of the intervertebral disc in an in vivo rat-tail model [J]. Med Eng Phys, 2004,26(7) : 587 -594.
  • 10Barbir A, Godbum KE, Michalek A J, et al. Effects of torsion on intervertebral disc gene expression and biomechanics, using a rat tail model[ J]. Spine (Phila Pa 1976) ,2011,36(8) : 607 -614.

二级参考文献36

  • 1应航,陈立,詹红生,井夫杰,吕荣坤.颈椎间盘退变的形态学观察和生物力学研究[J].中国医学物理学杂志,2005,22(2):460-462. 被引量：13
  • 2张嘉,叶启彬,邱贵兴,王以朋.不对称应力对脊柱终板生长的影响[J].中国矫形外科杂志,2005,13(11):843-845. 被引量：6
  • 3Pope MH,Goh KL,Magnusson ML. Spine ergonomics[J].Annu Rev Biomed Eng, 2002,4: 49.
  • 4Frymoyer JW,Pope MH,Clements JH, et al. Risk factors in low-back pain:an epidemiological survey [J].J Bone Joint Surg (Am), 1983,65 (2) :213-218.
  • 5Kelsey JL,Githens PB,White AA,et aLAn epidemiologic study of lifting and twisting on the job and risk for acutep rolapsed lumbar intervertebral disc[J].J Orthop Res, 1984,2 ( 1 ) : 61-66.
  • 6Hukins DW. A simple model for the function of proteoglycans and eollagen in the response to eomp ression of the intervertebral dise[J].Proc Biol Sci,1992,249(1326):281-285.
  • 7Rajasekaran S,Babu JN,Arun R. ISSLS prize winner:a study of diffusion in human lumbar discs:a serial magnetic resonance imaging study documenting the influence of the endplate on diffusion in normal and degenerate discs[J].Spine, 2004,29 (23) : 2654-2667.
  • 8Benneker LM,Heini PF,Alini M,et al.2004 Young Investigator Award Winner: vertebral endplate marrow contact channel occlusions and intervertebral disc degeneration[J].Spine,2005, 30(2) : 167-173.
  • 9Robert S,Urban JPG,Evans H.Transport properties of the human cartilage endplate in relation to its composition and calcification[J].Spine, 1996,21 ( 4 ) : 415 -420.
  • 10Zhao F,Pollintine P, Hole BD, et al. Diseogenic origins of spinal instability[J].Spine ,2005,30(23) :2621-2630.

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同济大学学报（医学版）
2016年 第1期

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