幽门螺杆菌感染与结直肠癌的关系探讨

Investigate the relationship of helicobacter pylori with colorectal carcinoma

目的探讨幽门螺杆菌(HP)与结直肠癌的关系。方法收集212例结直肠癌患者的标本和同期100例正常结直肠黏膜标本,用常规HE染色及免疫组织化学En Vision法染色检测HP。结果 100例正常结直肠黏膜组织中,8例检出HP,菌量为少量至中等量。212例结直肠癌病例中,92例检出HP,其中HP检出少量者44例,中等量37例,多量11例。HP与结直肠癌患者性别、年龄以及肿瘤的分化程度、TNM分期均无关联,但与肿瘤发生部位有关。结论 HP可能是结直肠癌的致病因素。

Objective To investigate the relationship of Helicobacter pylori（HP） with colorectal carcinoma. Methods 212 cases of colorectal carcinoma specimens and 100 cases of normal colorectal mucosa specimens were studied, with routine HE staining and immunohistochemical staining for the detecting HP. Results Eight in 100 cases of normal colorectal mucosa tissues were detected HP, of which inoculation amount was small to moderate. Ninety-two in 212 cases of colorectal carcinoma cases were detected HP, in which small amount of HP were detected in 44 cases, moderate amount of HP in 37 cases, massive amount of HP in 11 cases. HP were independent to gender, the degree of tumor differentiation, TNM stage and related to the locations of the tumor. Conclusion HP may be the causative factor of colorectal carcinoma.