细菌性中枢神经系统感染的实验室诊断研究进展

Advances in laboratory diagnosis of bacterial central nervous system infections

细菌性中枢神经系统感染是常见且严重的颅内感染性疾病,其早期实验室诊断对治疗和预后有重要作用。细菌性中枢神经系统感染的实验室诊断由脑脊液常规和生化等传统检测,逐渐发展为PCR技术、核酸杂交、16S r RNA测序以及基因芯片技术的多方法、多指标联合检测和多学科合作,促进了该病早期、快速的实验室诊断发展。本文就细菌性中枢神经系统感染的流行病学、常见致病菌及实验室诊断等方面进行了综述。

Bacterial central nervous system infection is a common and severe intracranial infectious disease, and its early laboratory diagnosis had an important role in the treatment and prognosis. The laboratory techniques for diagnosis of bacterial central nervous system infection experienced cerebrospinal fluid routine, biochemical and other traditional detections to PCR, nucleic acid hybridization, 16 S r RNA sequencing and microassay technology for multiple methods, multiple indexes and multidisciplinary cooperation, which promote the development of the early and rapid laboratory diagnosis. This paper reviewed about the epidemiology, common pathogens and the progress in laboratory diagnosis of bacterial central nervous system infection.