补土益水汤对去卵巢大鼠骨质疏松影响

Effect of Butu Yishui Decoction on Osteoporosis in Ovariectomized Rats

目的:探讨补土益水汤对去卵巢致骨质疏松症大鼠的作用。方法:以切除雌性大鼠双侧卵巢诱导骨质疏松为模型,观察补土益水汤对大鼠血清钙、磷含量,碱性磷酸酶(Alkalin phosphatase,ALP)、骨钙素(Bone Glaprotein,BGP)、抗酒石酸酸性磷酸酶(Tartrate-resisitant acid phosphatase,TRACP)含量测定,尿吡啶啉(Pyridinoline,PYD)/尿肌酐(Creatinine,Cr)及骨密度(Bone mineral density,BMD)等指标的影响。结果:补土益水汤可显著降低血清ALP、TRACP、BGP含量,降低PYD/Cr比值,增加骨密度。结论:补土益水汤对去卵巢所致的实验性骨质疏松症具有明显的改善作用。

Objective：To study the effects of Butu Yishui Decoction on osteoporosis in rats. Methods：The osteoporosis model was induced by the female ovariectomized rats to observe the function of Butu YishuiDecoction on blood calcium,blood phosphor,alkalin phosphatase（ALP）,bone Gla-protein（BGP）,tartrate-resisitant acid phosphatase（TRACP）,urine pyridinoline（PYD）/creatinine（Cr）and bone mineral density（BMD）. Results：Butu Yishui Decoction markedly decreased blood ALP,BGP,TRACP contents and Urine PYD/Cr ratio,increased the bone mineral density significantly. Conclusion：Butu YishuiDecoction has the obvious ameliorative effect on osteoporosis.