桐油对糖尿病大鼠血糖、血脂及肝肾功能影响

Impacts of Tung Oil on Plasma Glucose,Blood Lipid and Liver and Kidney Function in Rats with Diabetes Mellitus

目的:观察桐油对糖尿病大鼠血糖、血脂及肝肾功能的影响。方法:45只SD雄性大鼠,随机选取10只为正常组,余下的35只采用链脲佐菌素(35 mg·kg^(-1))一次性腹腔注射方法制作糖尿病大鼠模型。2周后,将血糖升高的大鼠随机分为模型组、桐油高剂量组、桐油低剂量组,每组10只,高脂饲料喂养。在给药7周、11周末,观察桐油对大鼠空腹血糖(FPG)、血胆固醇(TC)、甘油三酯(TG)、肝脏谷丙转氨酶(GPT)、谷草转氨酶(GOT)及血尿素氮(BUN)、肌酐(Cr)的影响。结果:与模型组相比,桐油组FPG显著降低,具有统计学差异(P<0.001或P<0.05),对血脂的影响不显著。与正常组相比,桐油组GPT、GOT、BUN、Cr值均出现了异常升高,表明桐油对大鼠的肝、肾功能均有毒性作用。结论:桐油中的药效成分桐酸可能是发挥降血糖作用的主要物质基础,并具有潜在的肝肾毒性。

Objective：To investigate the effects of tung oil on plasma glucose,blood lipid and liver and kidney function in rats with diabetes mellitus. Methods：Normal control group was established in 10 randomly selected from 60 SD rat. Another 35 rats induced by STZ（35 mg·kg^（-1））with single intraperitoneal injection were used to establish diabetic models. Two weeks later,rats with a high blood sugar were randomly divided into model groups,tung oil groups with high and low dosages respectively,10 in each group and feeding with high fat diet. At the end of 7 and 11 weeks,some indices were detected including the fasting blood glucose（FPG）,cholesterol（TC）,triglyceride（TG）,liver alanine aminotransferase（GPT）,aspartate aminotransferase（GOT）,urea nitrogen（BUN）and creatinine（Cr）. Results：Compared with the model group,the fasting blood glucose in the tung oil group was decreased obviously,with statistical difference（P〈0.001,P〈0.05）. No significance on blood lipids. Compared with the control group,the GPT,GOT,BUN and Cr in tung oil were raised to different levels. This showed that tung oil had toxicity effects on liver and kidney. Conclusion：Eleostearic acid is the main effective components of tung oil,may reduce the level of FPG,and has the potential of liver and kidney toxicity.