不同大孔树脂处理土鳖虫酶解液抗血栓作用研究

Antithrombotic Mechanmism of Eupolyphaga Enzymatic Hydrolyzate with Different Macroporous Resin

目的:研究不同大孔树脂处理后的土鳖虫酶解液的抗血栓作用。方法:以吸附率、得膏率和体外纤溶活性测定范围、血液黏度为指标,利用静态吸附试验对3种大孔树脂进行筛选。结果:DA201-C大孔树脂的吸附率最高,所处理的土鳖虫酶解液得膏率最低,体外纤溶活性测定范围最大,血液黏度最小。结论:采用DA201-C型大孔树脂对土鳖虫酶解液进行纯化处理,方法简便易行,抗血栓作用显著,可以达到预期目的。

Objective：Research of the antithrombotic mechanmism of the eupolyphaga enzymatic hydrolyzate with different type macroporous resins. Methods：Using adsorption rate,solids rate,vitro fibrinolytic activities and blood viscosity as the index,evaluat three different macroporous resin through the static adsorption experiment. Results：DA201-C type macroporous resin has the highest adsorption,eupolyphaga enzymatic hydrolyzate using this resin handle has the lowest solids rate,the vitro fibrinolytic activities strongest and the minimum blood viscosity. Conclusion：Using DA201-C macroporous resin to purificate for the eupolyphaga enzymolysis liquid,the method is simple,easy. It can achieve the expected purpose.