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JAK/STAT信号转导通路与脑保护的研究进展 被引量：3

Research Progress in JAK/STAT Signaling Pathway and Brain Protection
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摘要 Janus激酶-信号转导与转导激活子(JAK/STAT)信号转导通路作为一条重要的细胞内信号转导途径,广泛参与调控多种器官和组织的发育、分化、衰老和免疫调节等过程,近年来研究证实其与脑缺血后损伤、神经系统肿瘤病理过程及预后密切相关。本文综合分析JAK/STAT通路在脑缺血后处理中的机制,为临床发生缺血后行脑保护及全麻术中缺血再灌注损伤的治疗提供基础理论支持。 As an important intracellular signaling pathway,JAK/STAT pathway is extensively involved in the regulation of development,differentiation,aging and immune response in a variety of organs and tissues.In recent years,studies have confirmed that JAK/STAT pathway is closely related to the pathological process and prognosis of brain injury after cerebral ischemia and nerv-ous system neoplasms.This paper comprehensively analyzes the mechanism of action of JAK/STAT pathway in the ischemic postconditioning,which can provide theory support for the brain protection after cerebral ischemia and the treatment of brain injury during general anesthesia.
作者 潘青波 金孝岠 朋立超
机构地区 皖南医学院附属弋矶山医院麻醉科 复旦大学附属上海市第五人民医院麻醉科
出处 《南昌大学学报（医学版）》 CAS 2016年第1期88-91,共4页 Journal of Nanchang University：Medical Sciences
关键词 JAK/STAT 信号转导通路 脑缺血 脑保护 JAK/STAT signaling pathway cerebral ischemia brain protection
分类号 R743.3 [医药卫生—神经病学与精神病学]
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  • 1Reilly P. The impact of neurotrauma on society: an international perspective. Prog Brain Res 2007; 161: 3-9.
  • 2Imada K, Leonard WI. The Jak-STAT pathway. Mol Immunol 2000; 37: 1-11.
  • 3Linnekin D, Mou S, Deberry CS, Weiler SR, Keller JR, Ruscetti FW, et al. Stem cell factor, the JAK-STAT pathway and signal transduction. Leuk Lymphoma 1997; 27: 439-444.
  • 4Fenyo 1M, Florea IC, Raicu M, Manea A. Tyrphostin AG490 reduces NAPDH oxidase activity and expression in the aorta of hypercholesterolemic apolipoprotein E-deficient mice. Vascul Pharmacol201l; 54: 100-106.
  • 5Townsend KP, Shy tie DR, Bai Y, San N, Zeng J, Freeman M, et al. Lovastatin modulation of microglial activation via suppression of functional CD40 expression. J Neurosci Res 2004; 78: 167-176.
  • 6Delgado M. Inhibition of interferon (IFN) gamma-induced Jak-STATI activation in microglia by vasoactive intestinal peptide: inhibitory effect on CD40, IFN-induced protein-l 0, and inducible nitric-oxide synthase expression. J Bioi Chern 2003; 278: 27620-27629.
  • 7Zhao JB, Zhang Y, Li GZ, Su XF, Hang CH. Activation of JAK2/STAT pathway in cerebral cortex after experimental traumatic brain injury of rats. Neurosci Lett 2011; 498: 147-152.
  • 8Tsenter J, Beni-Adani L, Assaf Y, Alexandrovich AG, Trembovler V, Shohami E. Dynamic changes in the recovery after traumatic brain injury in mice: effect of injury severity on T2-weighted MRI abnormalities, and motor and cognitive functions. J Neurotrauma 2008; 25: 324-333.
  • 9Losiniecki A, Shutter L. Management of traumatic brain injury. Curr Treat Options Neurol 2010; 12: 142-154.
  • 10Onyszchuk G, He YY, Berman NE, Brooks WM. Detrimental effects of aging on outcome from traumatic brain injury: a behavioral, magnetic resonance imaging, and histological study in mice. J Neurotrauma 2008; 25: 153-171.

共引文献15

同被引文献18

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二级引证文献15

南昌大学学报（医学版）
2016年 第1期

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