加巴喷丁治疗老年顽固性皮肤瘙痒的临床研究

Clinical efficacy of gabapentin in the treatment of elderly resistant skin itching

目的探讨加巴喷丁治疗老年顽固性皮肤瘙痒的临床疗效和安全性。方法纳入2014年1月至12月,于我院皮肤与性病科门诊就诊的老年顽固性皮肤瘙痒患者200例,随机分为对照组和治疗组,每组各100例。治疗组患者服用加巴喷丁胶囊一日1次,每次0.3 g,对照组患者服用氯雷他定一日1次,每次10 mg,均为睡前服用,治疗2周,所有患者均按Dirk R Kuypers评分进行皮肤瘙痒程度评分,观察临床疗效和不良反应。结果治疗组治疗2周的总有效率和治愈率均高于对照组,两组差异具有统计学意义(P<0.05);与对照组比较,治疗组Dirk R Kuypers评分明显降低,且差异具有统计学意义(P<0.05);甲状旁腺激素、血尿素氮和血肌酐水平,治疗组也明显降低,且血清白蛋白水平明显升高,差异均具有统计学意义(P<0.05)。结论加巴喷丁可显著改善老年顽固性皮肤瘙痒临床症状,提高患者生活质量,且安全性高,临床值得推广应用。

Objective To investigate the clinical effect and safety of gabapentin in the treatment of elderly resistant skin itching. Methods A total of 200 elderly patients with resistant skin itching in our hospital from Jan to Dec 2014 were recruited. All of the subjects were equally divided into control group and treatment group randomly. The treatment group was given 0.3 g gabapentin every night before sleep, and the control group was given 10 mg claritin at the same time for two weeks. The Dirk R Kuypers score was measured, the clinical effect and adverse reactions were observed. Results The total effective rate and cure rate of treatment group were higher than those of control group（P〈0.05）. Compared with control group, the Dirk R Kuypers score and the PTH, BUN and Scr levels of treatment group were decreased significantly（P〈0.05）. However, the ALB level was increased significantly（P〈0.05）. Conclusion Gabapentin is good effective in the treatment of elderly resistant skin itching, and has a higher safety and lower adverse reaction.