妊娠相关血浆蛋白A在缺血性脑血管疾病预后中的应用

The Role of Pregnancy-associated Plasma Protein A in the Outcome of Ischemic Cerebrovascular Disease

探讨妊娠相关血浆蛋白A(PAPP-A)在缺血性脑血管疾病预后中的价值。检测短暂性脑缺血发作(TIA)患者、急性脑梗死患者和正常对照的血清PAPP-A水平,随访两年。PAPP-A浓度在TIA和急性脑梗死的预后不良组与预后良好组间有差异(P均<0.05),预后预测的OR值分别为1.41(P<0.05)和1.25(P<0.05)。笔者由此认为血清PAPP-A浓度对缺血性脑血管疾病预后有预测作用。

To investigate the role of pregnancy-associated plasma protein A （PAPP-A） in the outcome of ischemic cerebrovascular disease. The results showed that levels of PAPP-A in TIA patients, CI patients and normal control had significant differences （P〈0.05）. The follow-up results of TIA patients and CI patients indicated the PAPP-A concentration in the poor prognosis group were higher than those in the good prognosis group （P〈0.05, P〈0.05, respectively）. Serum PAPP- A concentration emerged as a predictor of risk stratification with an OR of 1.41 and 1.25 （P〈0. 05, P〈0.05）. So higher PAPP- A concentration has a forecasting value on prognosis in ischemic cerebrovascular disease.