2型糖尿病与乙肝肝硬化相关原发性肝癌的关系

Association of Type 2 Diabetes Mellitus and Hepatocellular Carcinoma in Patients with HBV-related Cirrhosis

为了探讨在乙肝肝硬化患者中，2型糖尿病与原发性肝癌之间的关系，回顾性分析2010年1月～2015年5月于辽宁医学院附属第一医院收治的733例乙肝肝硬化患者的相关临床资料。结果提示：糖尿病及HBUDNA阳性是乙肝肝硬化患者发生原发性肝癌的危险因素（OR值分别为2．650、23．982，P值均〈0．05），且糖尿病病程越长，发生原发性肝癌危险性越高（糖尿病病程于5年～10年者，其OR值为9．232；大于10年者，0R值为12．925）；乙肝肝硬化合并糖尿病患者，原发性肝癌的发生与糖尿病治疗方案无关（P〉0．05）；高胰岛素血症及胰岛素抵抗是乙肝肝硬化患者发展为原发性肝癌的危险因素（P〈0．05）。

To investigate the association between type 2 diabetes mellitus （T2DM） and hepatocellular carcinoma （HCC） in patients with HBV-related cirrhosis （HBC）, clinical data of 733 patients was retrospectively analyzed. All the patients were treated at the First Affiliated Hospital Liaoning Medical University, from January 2010 to May 2015. As a result, T2DM and HBV-DNA positive are the risk factors for HBC patients to get HCC （OR respectively are 2. 650 and 23. 982; P〈0.05）. The diabetes duration longer,the risk to suffering from HCC is higher （the duration 5-10 yrs, OR is 9. 232; the duration 〉10 yrs, OR is 12. 925）. To the HBC patients, the treatment of T2DM and the occurrence of HCC is irrelevant （P〉0.05）. Hyperinsulinemia and insulin resistance （IR） are the risk factors for the development of HCC in the patients with HBV-related cirrhosis.