绝经后2型糖尿病患者骨量下降与颅内动脉粥样硬化的关系

The Association between Decreased Bone Mass and Intracranial Atherosclerosis in Postmenopausal Women with Type 2 Diabetes Mellitus

为了探讨绝经后2型糖尿病(T2DM)妇女骨量下降与颅内动脉粥样硬化的关系,选取215例绝经后(T2DM)患者并根据骨密度将受试者分为骨量正常组和骨量下降组,比较两组患者的各项指标。结果显示骨量下降组患者的年龄、绝经年限、收缩压明显高于骨量正常组(P均<0.05),颅内动脉粥样硬化比例亦高于骨量正常组(P=0.001,P=0.000),且腰椎骨密度、股骨颈骨密度下降均是颅内动脉粥样硬化的独立危险因素(P均<0.05)。因此,骨量下降可能会增加绝经后T2DM患者颅内动脉粥样硬化的发生风险。

To investigate the association between decreased bone mass and intracranial atherosclerosis in postmenopausal women with type 2 diabetes, 215 postmenopausal women with type 2 diabetes were chosen and divided into normal bone mass group and decreased bone mass group, then compared the examination indexes of the two groups. The age, menopausal age and systolic blood pressure of decreased bone mass group were significantly higher than those of normal bone mass group （P〈0.05）, so were the proportion of intracranial atherosclerosis of decreased bone mass group （P= 0. 001,P = 0. 001）, and decreased bone mass of lumbar spine and femoral neck were independent risk factors of intracranial atherosclerosis （P〈0.05）. Therefore, decreased bone mass may increase the risk of occurrence of intracranial atherosclerosis for postmenopausal patients with T2DM.