浓缩前列安丸的干燥和成型工艺研究

Study on Drying and Molding Technology of Qianliean Concentrated Pills

目的优选浓缩前列安丸的最佳干燥和成型工艺。方法以浓缩比例、干燥温度、干燥时间和真空度为考察因素,以丹酚酸B含量和水分评分作为考察指标,采用正交实验优选浓缩前列安丸的干燥工艺。以推料速度、切丸速度、乙醇浓度和乙醇用量为考察因素,以成型率评分和崩解时限评分为考察指标优化其成型工艺。结果优化的最佳干燥工艺为浓缩比例为1:1.3,干燥温度为65℃,干燥时间为60 min,真空度为0.08 MPa。最佳成型工艺为乙醇浓度为80%,切丸速度为30 rpm,推料速度为30 rpm,乙醇用量为10%。结论优化后的工艺简便、易行、稳定,可用于浓缩前列安丸的批量生产。

Objective To optimize the best drying and molding technology of Qianliean concentrated pills. Methods Orthogonal test was employed for selecting the optimum drying technology of Qianliean concentrated pills by the content of salvianolic acid B and water content score, the factors to consider include the concentration ratio, drying temperature, drying time and vacuum degree. The molding technology was optimized with the molding rate and the time of disintegration score as index, and with the cutting speed, pushing time, concentration of ethanol and amount of alcohol as the factors. Results The best drying technology conditions were as follows： the concentration ratio was 1 ： 1.3, drying temperature was 65 ℃, drying time was 60 min and vacuum degree was 0.08 MPa. Meanwhile, the factors of optimum molding technology were that when the concentration of ethanol was 80%, the cutting speed was 30 rpm, the pushing speed was 30 rpm and the amount of ethanol was 10%. Conclusion The optimized process is simple, feasible and stable, which can be used for the mass production of Qianliean concentrated pills.