82例吉非替尼不良反应的文献分析

Literature Analysis of 82 Cases of Adverse Drug Reactions Induced by Gefitinib

目的分析吉非替尼致药品不良反应(ADR)相关规律和特点,发现吉非替尼使用风险点,为临床合理用药提供参照。方法以"吉非替尼"、"不良反应"、"致"、"gefitinib"等为检索词,检索中国期刊网全文数据库、维普中文期刊全文数据库,按纳入、排除标准共纳入57篇文献,并进行整理和分析。结果共提取82例病例,累及系统-器官主要为胃肠系统损害、皮肤及其附件损害、呼吸系统损害等,不良反应以腹泻、痤疮样皮疹、咳嗽、间质性肺炎等最为常见,严重可致死亡;病例多为男性中老年患者。结论重视吉非替尼在抗癌治疗中的不良反应,加强老年肺癌患者的用药监测,防范严重和罕见的不良反应发生。

Objective To investigate the characteristics and mechanism of adverse reactions induced by gefitinib, and to find its risk factors and provide technical support for safe and rational use of the drugs in clinic. Methods ＂Gefitinib＂, ＂adverse reaction＂ and ＂caused by＂ were used as key words to retrieve articles in CNKI and VIP database. 57 literatures which met the inclusion and exclusion criteria were extracted and analyzed. Results There were 82 cases of ADR in literatures, which mainly involved the gastrointestinal system, skin and appendages, respiratory system. Diarrhea, acne-like rash, cough, interstitial pneumonia were most common and some cases were serious even to death. The majority cases were senile male patients. Conclusion It is important to pay attention to the adverse reactions caused by gefitinib, especially to strengthen post-marketing surveillance for elderly lung cancer patients, so as to prevent severe and rare adverse drug reactions.