尿激酶静脉溶栓治疗急性脑梗死效果探讨

Effect of intravenous thrombolysis with urokinase on acute cerebral infarction

目的探讨急性脑梗死采用尿激酶静脉溶栓的治疗效果。方法选取安阳市人民医院脑血管科2013年3月至2014年3月收治的急性脑梗死患者80例，随机分为对照组与观察组，每组40例。对照组采用常规方案治疗，观察组加用溶栓治疗，比较两组疗效。结果观察组在溶栓后1、7、14d神经功能恢复情况均优于对照组，差异均有统计学意义（P〈0．05）。观察组临床总有效率为92．5％，明显高于对照组的67．5％，差异有统计学意义（P〈0．05）。用药过程中，观察组牙龈出血2例，无消化道出血及颅内出血病例。结论急性脑梗死采用尿激酶静脉溶栓治疗可促进神经功能恢复，提高临床效果，并具一定安全性，有较高的应用价值。

Objective To investigate the effect of intravenous thrombolysis with urokinase on acute cerebral infarction. Methods From March 2013 to March 2014, 80 patients with acute cerebral infarction in the people＇ s hospital of Anyang were selected, and randomly divided into control group and observation group, with 40 cases in each group. The patients in control group were given conventional regimen treatment, and the patients in observation group were given thrombolytic therapy in addition. The effects of the two groups were compared. Results The observation group was superior to the control group in neurological recovery on 1 st, 7th, 14th day after thrombolysis, the difference was significant （P 〈 0. 05 ）. The total effective rate in observation group was 92. 5%, which was significantly higher than that in control group（67. 5% ）, the difference was significant （P 〈 0. 05）. During the medication, there were 2 cases of gums bleeding in observation group, no case of gastrointestinal bleeding or intracranial hemorrhage. Conclusions Acute cerebral infarction using urokinase thrombolytic therapy can promote the recovery of neurological function and improve the clinical results, has a certain security and high application value.