多囊卵巢综合征不孕患者促排卵药物疗效对比

Efficacy comparison of ovulation induction on infertility patients with polycystic ovary syndrome

目的比较多囊卵巢综合征不孕患者促排卵药物的疗效。方法随机选取2013年10月至2014年10月多囊卵巢综合征不孕患者80例，分为研究组（来曲唑组）与对照组（氯米芬组）．每组40例。对比观察两组患者治疗后排卵与妊娠情况。结果研究组患者优势卵泡率为86．11％，对照组为59．21％；研究组患者排卵率为88．71％，对照组排卵率为64．44％；研究组患者妊娠率为40．00％，对照组妊娠率为20．00％；差异均有统计学意义（P〈0．05）。结论相对于氯米芬，来曲唑应用于多囊卵巢综合征不孕患者，能更好的诱导优势卵泡生长发育，取得更佳的子宫内膜环境，提升妊娠率，值得临床推广应用。

Objective To compare the effect of ovulation induction on infertile patients with polyeystic ovary syndrome. Methods From October 2013 to October 2014, 80 infertile patients with polycystic ovary syndrome were divided into study group （letrozole group） and control group （clomiphene group） , with 60 cases in each group. Ovulation and pregnancy was observed after treatment. Results The dominant follicle rate was 86. 11% in study group, and was 59.21% in the control group; the ovulation rate in study group was 88.71% , and was 64. 44% in the control group; the pregnancy rate in study group was 40.00% , and was 20. 00% in the control group, the differences were significant（P 〈 0.05 ）. Conclusions Compared to clomiphene, letrozole in treatment of infertile patients with polycystic ovary syndrome, can better induce the dominant follicle growth, achieve better endometrial environment, improve the pregnancy rate, is worthy of clinical application.