孕妇妊娠期高血压疾病与血清钙、25羟维生素D3等生化指标的相关性研究

Study on the correlation between hypertensive disorder complicating pregnancy and serum calcium,25-hydroxy vitamin D_3

目的探讨妊娠期高血压疾病孕妇血清钙(Ca)、磷(P)代谢的改变及其临床意义。方法选取宁波市妇女儿童医院2013年6月-12月收治的62例中重度妊娠期高血压疾病孕妇作为观察组。随机选取同期的62例正常孕妇作为对照组。采用生化仪或化学发光仪测定并比较2组孕妇的血清Ca、P、25羟维生素D3[25(OH)D3]、碱性磷酸酶(AKP)、甲状旁腺素(PTH)、降钙素(CT)、骨钙素(BGP)、总胆固醇(CHOL)及甘油三酯(TG)的含量。结果 2组孕妇在Ca、P、AKP、PTH、CT、25(OH)D3、BGP、TG、CHOL上差异均有统计学意义(t值分别为1.98、1.82、2.62、2.02、2.23、2.02、2.23、1.85和2.13,P<0.05)。Logistic回归分析各生化指标对是否有高血压的影响差异均有统计学意义(OR值分别为0.084、0.860、1.083、0.548、1.220、1.203、0.922、1.109和1.006,P<0.05)。其中,PTH、P、CHOL、AKP、TG对是否有高血压的影响为正向,CT、Ca、25(OH)D3对是否有高血压的影响为负向。结论血清Ca、P、25(OH)D3等指标可作为孕妇妊娠期高血压疾病的观察指标,具有重要的意义。

Objective To explore the changes of serum calcium and phosphorus levels in pregnant women with hypertensive disorder complicating pregnancy（ HDCP） and the clinical significance. Methods Sixty-two pregnant women with moderate-severe HDCP treated in the hospital from June to December in 2013 were selected as observation group. Sixty-two normal pregnant women during the same period were randomly selected as control group. Biochemical analyzer or chemiluminescence apparatus was used to detect and compare the contents of calcium,phosphorus,25-hydroxy vitamin D_3,alkaline phosphatase（ AKP）,parathyroid hormone（ PTH）,calcitonin（ CT）,bone gla protein（ BGP）,total cholesterol（ CHOL）,and triglyceride（ TG） between the two groups. Results There were statistically significant differences in calcium,phosphorus,AKP,PTH,CT,25-hydroxy vitamin D3,BGP,TG,and CHOL levels between observation group and control group（ t = 1. 98,1. 82,2. 62,2. 02,2. 23,2. 02,2. 23,1. 85,and 2. 13,P〈0.05）. Logistic regression analysis showed that the above-mentioned biochemical indexes had significant impacts on hypertension（ OR = 0. 084,0. 860,1. 083,0. 548,1. 220,1. 203,0. 922,1. 109,and 1. 006,P〈0.05）. The impacts of PTH,phosphorus,CHOL,AKP,and TG on HDCP were positive,while the impacts of CT,calcium,and 25-hydroxy vitamin D_3 on HDCP were negative. Conclusion Serum calcium,phosphorus,25- hydroxy vitamin D_3 can be used as indexes to observe HDCP,which have important significance.