摘要
许多病毒感染可导致肿瘤发生,这些病毒虽隶属于不同种属,但其进化出的分子干扰机制却有共通之处,即靶向调控与细胞生长和增殖相关的关键蛋白。病毒和宿主之间的相互作用也发生于表观遗传水平。本文对DNA病毒导致癌症发生的表观遗传机制进行综述。
Various kinds of virus could lead to carcinogenesis. Although those viruses belong to different viraceae, the molecular mechanisms they have evolved to cause tumor initiation show many similarities, which are targeting the key cellular proteins that regulate cell growth and proliferation. The interactions between virus and hosts occur at epigenetic level. This review summarizes the epigenetic mechanism of DNA virus proteins contributing to carcinogenesis.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2016年第3期230-233,共4页
Cancer Research on Prevention and Treatment
基金
湖北省自然科学基金面上项目(2014CFB372)
