促炎症因子与骨性关节炎关系的研究进展

Research progress of the association between pro-inflammatory cytokines and osteoarthritis

骨性关节炎(OA)是我国老年人关节疼痛和功能障碍的主要原因,发病率逐年上升。除关节周缘骨赘增生和关节软骨退变外,炎症作为OA重要的病理改变之一,受到越来越广泛的关注。促炎症因子是炎症反应重要的媒介,OA中促炎症因子水平升高,导致全身和局部的炎症反应,加速包括关节软骨在内的多种组织结构破坏,促进OA进展的理念已被广大学者接受。此外,炎症严重程度和OA的临床表现密切相关。因此,深入了解各种促炎症因子在OA发病中的作用具有重要的临床意义。本文从促炎症因子与OA的关系及分子机制角度入手,对该领域的研究进展作一综述,为OA的临床诊治提供新的视角。

Osteoarthritis（OA） is the main reason of joint pain and dysfunction in the elderly in China, and its incidenceis increasing year by year. In addition to the joint peripheral osteophyte formation and degeneration of articular cartilage, in-flammation, as one of the dominant pathological changes in OA, is causing more and more attention. Pro-inflammatory cyto-kines（PIC） are important mediators of inflammation. The increased level of PIC in OA can lead to systemic and local inflam-mation, results in further destruction of many kinds of tissues in joint（such as cartilage）, and accelerates the development ofOA. Besides, the severity of inflammation is closely related to the clinical symptoms of OA. Therefore, it is important to un-derstand the role of PIC in the pathogenesis of OA. From the perspective of the relationship between pro-inflammatory fac-tors and OA and the molecular mechanism, this article reviews the research progress in this field, which provides new con-cepts for diagnose and treatment of OA.