创伤后细胞因子改变的意义及针对细胞因子相关治疗的研究进展

The clinical significance of cytokine＇ s changes after trauma and the progress of the research in the treatment about cytokines

严重创伤可以通过启动神经一内分泌一免疫系统，促使大量细胞因子的释放，诱导全身炎性反应（SIRS）的产生，同时，各细胞因子间通过复杂的交互网络，产生级联放大效应，促进SIRS的发展，最终导致多器官功能障碍（MODS）甚至衰竭（MOF）。当前，与细胞因子相关的治疗研究较多，包括细胞因子拮抗治疗、基因治疗、血液净化治疗等等。本文将阐述创伤后主要细胞因子改变的意义，同时简要介绍针对细胞因子的相关治疗。

Severe trauma can promote the release of a large amounts of cytokines by starting the nerve - endo- crine - immune system, then , induce systemic inflammatory response syndrome （SIRS）. At the same time, the cytokines cause cascade amplification and promote SIRS developing by complex interactive networks, eventually leading to multiple organ dysfunction syndrome （MODS） and failure （MOF）. At present, there are many researches about the treatment of cytokines, including the treatment of cytokine antagonists,Gene therapy, blood purification therapy, etc. This article will describe the significance of the changes of the main cytokines after trauma, and briefly introduce the treatment of eytokines.