B 型尿钠肽与2型糖尿病发生风险相关

B-type natriuretic peptide and risk of type 2 diabetes mellitus

目的：研究氨基末端前B型尿钠肽（NT-proBNP）与2型糖尿病发病的独立相关性。方法对经糖耐量试验（OGTT）确定为糖调节受损人群随访2年（n＝126），在基线时抽取受试者静脉血测定血浆中NT-proBNP。结果基线时NT-proBNP与体重指数、腰围、空腹血糖、空腹胰岛素、低密度脂蛋白胆固醇（ LDL-C）负相关。在随访2年时，有51例新发糖尿病。经过多变量分析调整后，基线NT-proBNP仍与糖尿病风险负相关，调整的相对危险度在第1～4四分位数组分别为1．0（参照）、0．83（95％CI 0．74～0．96）、0．78（95％CI 0．68～0．90）、0．74（95％CI 0．64～0．87；P＜0．01）。结论在糖调节受损人群中，低水平的NT-proBNP与糖尿病风险升高相关。

Objective To explore the association of NH2-terminal pro-B-type natriuretic peptide （ NT-proBNP） with the risk of type 2 diabetes.Methods One hundred and twenty-six impaired glucose regulation（ IGR） participants from Diabetic Identification Center of Tianjin Metabolic Diseases Hospital were included.NT-proBNP was measured in plasma samples collected from participants at baseline condition.Results At baseline, NT-proBNP was inversely associated with body mass index, waist circumference, fasting glucose, insulin and low-density lipoprotein-cholesterol（ LDL-C） levels.During a follow-up of 2 years, 51 participants reported a new diagnosis of diabetes from OGTT.Baseline quartiles of NT-proBNP were inversely associated with diabetes risk, even after multivariable adjustment.Theadjustedrelativerisksfordiabeteswere1.0（reference）,0.83（95%CI0.74-0.96）,0.78（95%CI 0.68-0.90）, 0.74 （95%CI 0.64-0.87） for the 1st, 2nd, 3rd, and 4th quartiles of baseline NT-proBNP, respectively （ P〈0.01 ） .Conclus ion In IGRpopulation , lowlevels of NT-proBNP were associated with a significantly increased risk of type 2 diabetes.