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免疫检验点阻断:癌症免疫治疗的新希望 被引量:1

Blockade of Immune Checkpoints:New Hope for Cancer Immunotherapies
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摘要 免疫检验点是T细胞激活的负调节分子,阻断这些分子的活性可提升T细胞对癌细胞的杀伤能力,临床试验显示出良好效果,提示了癌症免疫治疗的一个新方向,也引起了癌症免疫治疗的一场新热潮。 The blockade of immune checkpoints is a new idea for cancer immunotherapies.Several monoclonal antibodies targeting immune-checkpoint molecules have been developed.The outcomes of clinical trials indicate important advances in treating many kinds of cancers.An evaluation of the new therapies is made in this article.
出处 《科学》 2016年第2期20-23,4,共4页 Science
基金 河北省自然科学基金(H2014205082) 河北省卫生厅指令性课题(20130113)资助
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