住院患儿急性呼吸道病毒感染病原学调查

Etiology of acute respiratory viral infections in hospitalized children

目的了解和准确掌握卫辉市急性呼吸道病毒感染患儿的病原体分布及相关临床特征,为急性呼吸道病毒感染的临床防治提供借鉴和参考依据。方法选取2012年12月-2013年12月入医院接受治疗的484例急性呼吸道感染住院患儿为研究对象,针对患儿的鼻咽部分泌物进行了实验室的病毒检测。结果 484例急性呼吸道感染患儿中病毒感染有230例占47.52%;检出病毒共244株,其中流感病毒65株占13.43%,呼吸道合胞病毒128株占26.45%,腺病毒17株占3.51%,副流感病34株占7.02%;男性患儿呼吸道合胞病毒感染率显著高于女性患儿,差异有统计学意义(χ2=4.2235,P<0.05);>4岁患儿的腺病毒感染率显著高于其他年龄组患儿,差异有统计学意义(χ2=23.54,P<0.01)。结论卫辉市急性呼吸道感染住院患儿发病的主要病毒为呼吸道合胞病毒和流感病毒,患儿的临床症状存在一定程度的差异。

OBJECTIVE To investigate the distribution of pathogens causing acute respiratory viral infections in children of Weihui area and analyze the related clinical characteristics so as to provide guidance for clinical prevention and treatment of the acute respiratory viral infections.METHODS A total of 484 hospitalized children with acute respiratory infections who were treated in the hospital from Dec 2012 to Dec 2013 were recruited as the study objects,then the nasopharyngeal secretions were collected for laboratory virus detection.RESULTS Of the 484 children with acute respiratory infections,230（47.52%）had viral infections,including 65（13.43%）cases of influenza virus infections;128children had respiratory syncytial virus（RSV）infections,with the infection rate of26.45%;17children had adenovirus（ADV）infections,with the infection rate of 3.51%;34children had parainfluenza virus（PIV）infections,accounting for 7.02%.The incidence of RSV infections was significantly higher in the male children than in the female children（χ^2=4.2235,P〈0.05）.The incidence of ADV infections was significantly higher in the children aged more than 4years old than in other age groups of children（χ^2=23.54,P〈0.01）.CONCLUSIONThe RSV and influenza virus are dominant among the viruses causing the acute respiratory infections in the hospitalized children,and there is certain difference in the clinical symptoms among the children.