游离氨基酸配方营养粉在牛奶过敏性婴儿湿疹中的应用

The Study on the Clinical Effect of AAF on the Infantile Eczema

目的探讨游离氨基酸配方营养粉（AAF）辅助婴儿湿疹治疗的临床效果。方法选择2013—2014年在哈尔滨市儿童医院皮肤科确诊的人工喂养湿疹患儿109例,2~6个月龄,给予AAF替代喂养,期间回避鸡蛋、奶制品等易引起过敏的食物。采用SCORAD评分系统对入组患儿替代喂养前,连续替代喂养2周、4周及3个月的湿疹情况进行评估。结果连续采用AAF替代喂养2周、4周及3个月,时痊愈率分别为28.4%、46.7%和59.8%,随着AAF替代喂养时间的延长痊愈率提高,差异并具有统计学意义（P〈0.05）;其中轻中度和重度患儿在替代喂养2周、4周及3个月时痊愈率分别为33.7%、46.0%、59.1%和5.0%、50.0%、63.2%;痊愈率均与AAF替代喂养时间呈正相关（P〈0.05）,其中重度患儿痊愈率提高更为明显。AAF替代喂养不同时期的患儿总有效率均达到了95%以上,研究过程中未出现严重不良反应。结论通过AAF辅助婴儿湿疹治疗可有效提高湿疹患儿的疗效,尤其是重度患儿,痊愈率提高显著。

OBJECTIVETo study the clinical effect of amino acid formula powder（AAF） on the progress of infantile eczema. METHOD The 109 diagnosed infantile eczema children aged 2 to 6 months from 2013 to 2014 were selected. The AAF was used as bottled feed-ing,avoiding the contact with the common food allergens during the feeding, such as dairy,egg,et al. The SCORAD evaluationsystem was used to assess the extent and severity of eczema at 4 points： before the AAF feeding, AAF feeding for 2 weeks, 4weeks and 3 months. RESULTS The total recovery rate after AAF feeding for 2 weeks,4 weeks and 3 months are 28.4%、46.7%、59.8% respectively. The total recovery rate has been greatly improved with the time of AAF feeding（P〈0.05）. For the mild to moder-ate case, the recovery rate after AAF feeding for 2 weeks, 4 weeks and 3 months were 33.7%, 46.0% and 59.1% respectively.5.0%, 50.0% and 63.2% for the severe, respectively. The recovery rate average was a positive relationship with the time of AAFfeeding（P〈0.05）,especially for the severe cases. The total response rate at different time points was above 95%,and no adverse ef-fect was observed. CONCLUSION The AAF could help to cure the progress of infantile eczema and greatly improve the recoveryrate,especially for the severe cases.