结直肠癌腹腔镜手术与开腹手术远期疗效比较的Meta分析

Long- term Outcomes of Laparoscopic and Open Surgery for Colorectal Cancer： A Meta- analysis

目的比较腹腔镜手术与开腹手术治疗结直肠癌的远期疗效。方法检索1991年1月至2015年1月间发表的对比结直肠癌腹腔镜手术与开腹手术远期疗效的随机对照试验，用Review Manager5．2软件进行统计学分析。结果纳入13项研究共计4966例结直肠癌患者，其中腹腔镜手术2611例，开腹手术2355例。与开腹手术相比，腹腔镜结直肠癌手术的总体复发率、局部复发率、远处转移率、切口复发率、总体死亡率、肿瘤相关死亡率、3年生存率、5年生存率、3年无病生存率及5年无病生存率差异均无统计学意义（P〉0．05）。结论腹腔镜结直肠癌手术远期疗效方面与开腹手术相当。

Objective To compare long - term outcomes of laparoscopic colorectal surgery （LCS） and open colo- rectal surgery（OCS） for colorectal cancer. Methods Randomized controlled trials comparing long - term outcomes of laparoscopic versus open surgery for colorectal cancer from Jan. 1991 to Jan. 2015 were searched and analyzed using RevManS. 2 software. Results Thirteen studies with 4 966 patients with colorectal cancer were included, of whom 2 611 underwent laparoscopic surgery and 2 355 underwent open surgery. There were no significant differences in overall recurrence rate, local recurrence rate, distant metastasis rate, incision recurrence rate, overall mortality rate, cancerrelated mortality rate, 3 -year survival rate, 5 -year survival rate, 3 -year disease -free survival rate and 5 - year disease - free survival rate between LCS group and OCS group （ P 〉 0.05 ）. Conclusion Long - term out- comes of LCS and OCS for colorectal cancer are similar.