含左氧氟沙星方案治疗肺结核强化治疗期合并糖尿病的疗效及安全性分析

Observational study on treatment outcome and safety of levofloxacin-containing in treating intensive phase treatment pulmonary tuberculosis accompanied with diabetes mellitus

目的探讨含左氧氟沙星方案治疗肺结核强化治疗期合并糖尿病的疗效及安全性。方法将肺结核合并2型糖尿病患者124例随机分为观察组和对照组各62例。两组患者均采用2-3HRZE/4-6HR方案进行治疗,观察组患者在强化期加口服左氧氟沙星片治疗。对比分析治疗后3个月、6个月、9个月两组患者的痰涂片、肺部CT检查结果及不良反应。结果治疗3个月后,观察组患者的痰菌转阴率为82.26%,病灶显著吸收率为75.81%,空洞闭合率为77.42%,均显著高于对照组,分别为58.06%,53.23%,51.61%(P<0.05);治疗6个月、9个月后两组患者的痰菌转阴率、病灶显著吸收率和空洞闭合率比较,差异无统计学意义(均P>0.05);治疗过程中,两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论强化期含左氧氟沙星方案治疗可缩短肺结核合并糖尿病患者的痰菌转阴、病灶吸收时间,安全性良好,值得推广应用。

Objective To investigate the treatment outcome and safety of levofloxacin-containing in treating intensive phase treatment pulmonary tuberculosis accompanied with diabetes mellitus. Methods One hundred and twenty-four pulmonary tuberculosis accompanied with diabetes mellitus were randomly divided into observation group and control group,with 62 cases in each group. All patients received anti-tuberculosis treatment of 2-3HRZE /4-6HR,and observation group received levofloxacin in treatment enhancement period. Sputum smears,examination results of lung CT and adverse reaction between the two groups were compared after treatment for 3 months,6 months,9 months. Results After treatment for 3 months,the sputum negative conversion rate,lesions absorption rate and tuberculosis cavities occlusion rate in observation group were 82. 26%,75. 81% and 77. 42%,respectively,which were significantly higher than those in the control group( 58. 06%,53. 23%,51. 61% respectively,P < 0. 05). However,no significant differences were found in the sputum negative conversion rate,lesions absorption rate and tuberculosis cavities occlusion rate between two groups after treatment for 6 months 6 and 9 months( P > 0. 05). There were also no significant differences in incidence of adverse events between two groups( P > 0. 05). Conclusions Levofloxacin-containing in treating intensive phase treatment pulmonary tuberculosis accompanied with diabetes mellitus is safe,which can shorten the time of the negative transformation of sputum bacterium and promote lesions absorption,and worth to be widely used.