乳腺癌组织中HPA蛋白的表达及其与ER、PR、HER-2、P53表达的相关性

Expression of HPA Protein and the Correlations with ER,PR,HER-2,P53 Protein Expressions in the Breast Cancer

目的探讨乙酰肝素酶(heparanase,HPA)蛋白在乳腺癌组织中表达的临床意义及其与雌激素受体(ER)、孕激素受体(PR)、人类表皮生长因子受体2(HER2)、P53表达的关系。方法采用免疫组化S-P法检测78例乳腺癌组织中HPA蛋白的表达。结果 HPA蛋白在乳腺癌组织中的阳性表达率为69.2%。HPA蛋白在乳腺癌组织中的表达与乳腺癌患者年龄、肿瘤大小无关(P>0.05),与淋巴结转移、临床分期有关(P<0.05)。HPA蛋白在乳腺癌组织中的表达与ER、PR蛋白的表达无明显相关性(r=0.178、0.056,P>0.05),与HER-2、P53蛋白表达呈正相关关系(r=0.436、0.310,P<0.05)。结论 HPA蛋白可能与乳腺癌疾病进展有关,且与HER-2、P53蛋白表达呈正相关关系。

Objective To investigate the expression of heparanase（ HPA） and the correlations with estrogen receptor（ ER）,progesterone receptor（ PR）,human epidermal growth factor receptor-2（ HER-2）,P53 protein expressions in the breast cancer. Methods The expressions of HPA protein were detected in the 78 cases of breast cancer by immunohistochemistry S-P method. Results The positive expression rate of HPA protein was 69. 2% in the breast cancer. The expression of HPA protein was not correlated with the age of patient and size of mass in the breast cancer（ P〉0. 05）; but was correlated with the lymph node metastasis and the clinical stage of breast cancer（ P 〈0. 05）. There were no correlations between the expression of HPA protein and the expression of ER or PR protein（ r = 0. 178,0. 056; P 〉0. 05）; The expression of HPA protein was positively correlated with the expression of HER-2 and P53 protein（ r = 0. 436,0. 310; P 〈0. 05）. Conclusion HPA protein is correlated with progression of breast cancer,and is positively correlated with the HER-2 and P53.