夏枯草对肥胖小鼠糖脂代谢的影响

Studying of the Prunella vulgaris L.effect on carbohydrate and lipid metabolism in the obese mice

目的:研究夏枯草对高脂饮食诱导的肥胖小鼠体重和血脂的影响,探讨夏枯草治疗肥胖的可行性。方法:C57BL/6J雄性小鼠以高糖高脂饲料喂养12周,进行肥胖模型的建立,建模成功后,分别为正常组、模型组、阳性药非诺贝特组、夏枯草高低剂量组,每天灌胃给药1次,给药8周后测定相关指标。结果:夏枯草能有效降低肥胖小鼠的TG、TC、LDL,并升高HDL(P<0.05)。结论:夏枯草能够调整脂代谢,有效地降低总胆固醇和低密度脂蛋白胆固醇,从而达到治疗肥胖的目的。

Objective： To study the effect of Prunella vulgaris L. on body weight and lipid in the obese mice,and explore the feasibility of Prunella vulgaris L. treatment of obesity. Methods： Feed the C57 BL / 6J male mice with high sugar high fat diet for 12 weeks to established obesity models.After successful modeling,they were randomly divided into five groups：normal group,model group,positive drug fenofibrate group,Prunella low-dose group and Prunella high-dose group.Daily oral administration of 1.After 8 weeks of administration,determinating relevant indexes.Result It turned out that Prunella can effectively reduce obesity in mice TG,TC,LDL and elevated HDL（P0.05）.Conclusion Prunella vulgaris L. can adjust lipid metabolism,effectively reducing the total cholesterol and LDL cholesterol,so as to achieve the effect of the treatment of obesity.