吡柔比星诱导膀胱癌细胞凋亡的实验研究及预防膀胱癌术后复发的效果

Experimental study pirarubicin induce apoptosis in bladder cancer cells and prevent recurrence of bladder cancer effect

目的：探讨不同浓度的吡柔比星对膀胱癌细胞凋亡的作用及预防膀胱癌术后复发的临床效果。方法：抽取2012年3月~2013年11月本院接诊的46例经尿道电切术的膀胱移行细胞癌患者作为研究对象,分析不同药物浓度对膀胱癌细胞增殖分化的抑制效果,同时对患者予以吡柔比星的膀胱内灌注治疗。结果：随着吡柔比星浓度的升高,T24细胞生长抑制率呈现增强的趋势,100mg/L的浓度诱导细胞凋亡效果最好。随访2年,46例患者中仅3例（6.5%）复发。结论：吡柔比星可有效诱导膀胱癌细胞凋亡,增加药物的浓度可获得更好的抑制效果,该药物有效预防术后复发,值得推广。

Objective：To explore the concentrations of pirarubicin apoptosis of bladder cancer and the prevention of recurrence of bladder cancer clinical effect. Methods：Extraction March 2012 ~ November 2013 hospital admissions of 46 cases of transurethral resection of bladder transitional cell cancer patients for the study,analysis of different drug concentrations in bladder cancer cell proliferation and differentiation inhibitory effect,while THP within the patient to be the star of intravesical chemotherapy. Results：With pirarubicin concentration rising,T24 cell growth inhibition rate also showed increasing trend,100 mg / L concentration induced apoptosis best. 2-year follow-up,46 patients,only 3 cases（6.5%）relapsed. Conclusion：pirarubicin can effectively induce apoptosis in bladder cancer cells,increasing the concentration of the drug achieved better suppression effect,and the drug effective in preventing the recurrence rate of patients after surgery,it is worth promoting.