吸入糖皮质激素对COPD患者呼出气一氧化氮水平影响

Effect of inhalde Glucocorticoids on the level of exhaled nitric oxide in patients with chronic obstructive pulmonary disease(COPD)

目的：探讨吸入糖皮质激素对COPD患者呼出气一氧化氮水平影响。方法：选取2015年2~8月于贵州省人民医院门诊就诊的初治慢阻肺患者36例（未系统治疗,近半年未使用激素及其他抗生素等）,其中18例为慢性阻塞性肺疾病急性加重期,18例慢性阻塞性肺疾病稳定期。健康组41例。AECOPD组、COPD稳定期组、正常对照组分别测出FENO,AECOPD组、COPD稳定期组经吸入糖皮质激素有效治疗复测FENO。分析治疗前后FENO的变化。结果：慢性阻塞性肺疾病急性加重期FENO（26.81±16.42）ppb,COPD稳定期FENO（21.32±11.73）ppb,治疗前COPD组均高于正常对照组,AECOPD治疗前FENO高于COPD稳定期治疗前,AECOPD治疗后FENO高于COPD稳定期治疗后。结论：FENO测定是无创的、简便的、易行的,对慢性阻塞性肺疾病疗效评价及预测有一定的临床应用价值。

Objective：To investigate the effect of inhalde Glucocorticoids on the level of exhaled nitric oxide in patients with chronic obstructive pulmonary disease（COPD）.Methods：A total of 36 People who were 18 cases of acute exacerbation of chronic obstructive pulmonary disease（AECOPD）,18 cases of stable phase of chronic obstructive pulmonary disease,had not used any Glucocorticoids or other drugs such as Montelukast Sodium and aminophylline, etc.within half a year with newly diagnosed chronic obstructive pulmonary disease from February 2015 to May 2015 in the Guizhou Provincial People＇s Hospital＇s chronic obstructive pulmonary disease clinic were included in the studies.Their FENO was measured respectively.FENO of 15 normal People which were treated as control group.Analyzed the FENO changes,before and after treatment.Results：People with acute chronic obstructive pulmonary disease（ACOPD）,FENO were（26.81 ±16.42） ppb.People with chronic obstructive pulmonary disease（COPD） stablization,FENO were（21.32±11.73）ppb.Both were higher than that in normal people,ACOPD had much higher value than that in the people with chronic obstructive pulmonary disease（COPD） stablization group. Conclusion：FENO examination is uninvasive,easy and useful in evaluating and predicting the response to treatment in COPD patients.