盐酸氨溴索不同给药方式对儿科呼吸系统疾病临床疗效的影响

Influence of Different Drug Administration of Ambroxol Hydrochloride on the Treatment Efficacy of Pediatric Respiratory Disease

目的：比较盐酸氨溴索不同给药方式治疗儿科呼吸系统疾病的临床疗效.方法：选取某院儿科2013年5月-2014年5月收治呼吸系统疾病患儿150例作为研究对象,按照给药方式划分为3组,其中对照组1雾化吸入生理盐水,对照组2给药方式为静脉滴注盐酸氨溴索,观察组为雾化吸入,对比3组临床疗效及不良反应发生率.结果：观察组总有效率为96.0%,明显高于对照组1的70.0%与对照组2的82.0%,且对照组2明显优于对照组1,对比差异明显（P 〈0.05）;观察组不良反应发生率为4.0%,与对照组1的4%相同.与对照组2的14.0%,对比差异有统计学意义（P 〈0.05）.结论：盐酸氨溴索用于治疗儿科呼吸系统疾病临床疗效优良,且雾化吸入给药方式效果优于静脉给药方式,且安全性更高,有推广价值.

Objective:To compare the clinical curative effect of different drug administration of ambroxol hydrochloride in treating pediatric respiratory disease.Methods:150 cases of children with respiratory disease in a hospital from May 2013 to May 2014 were randomly divided into three groups according to drug adminis-tration,control 1 group was given inhaled normal saline,control 2 group was given intravenous infusion of ambroxol hydrochloride,the observation group was given inhaled ambroxol hydrochloride,compare the clini-cal curative rate and adverse reaction incidence of the three groups.Results:The total effective rate of the ob-servation group was 96.0%,significantly higher than the 70.0% of the control 1 group and the 82.0% of the control 2 group,and control 2 group was significantly better than control 1 group,the difference was statisti-cally significant (P<0.05).The adverse reaction incidence of the observation group was 4.0%,the same as that of the control 1 group,the adverse reaction incidence of the control 2 group was 14.0%,the difference was statistically significant (P<0.05).Conclusion:Ambroxol hydrochloride has remarkable curative effect in treating pediatric respiratory disease,and inhaling administration is better than intravenous infusion adminis-tration,it is safer and is worth promotion.