卵巢癌腹水中血管内皮生长因子的表达及临床意义

The expression and significance of ascitic vascular endothelial growth factor in epithelial ovarian cancer

目的探讨卵巢癌恶性腹水中血管内皮生长因子（VEGF）水平与临床病理因素之间的相关性。方法采用EHSA方法检测148例卵巢癌患者恶性腹水中VEGF的表达。结果卵巢癌组腹水中VEGF表达水平为（909．16±583．15）pg／ml，显著高于良性组的（258．13±127．82）pg／ml，两组差异有统计学意义，其VEGF的表达与淋巴结转移及临床分期相关（P〈0．05）。VEGF高表达患者（≥613．38pg／m1）的生存期c（9．98±0．68）月]明显低于VEGF含量低的（〈613．38pg／m1）患者的生存期[（23．64±0．65）月]，差异有统计学意义。多因素Cox回归分析结果显示腹水VEGF值与卵巢癌患者的生存期明显相关（P〈0．001）。结论腹水YEGF值可成为卵巢癌患者独立预后指标。

[Abstract] Objective To examine the expression and significance of vascular endothelial growth factor （VEGF） in ascitic fluid from patients with epithelial ovarian cancer. Methods The study included 148 consecutive ovarian cancer patients with malignant ascites. VEGF levels in ascites were determined by a sandwich enzyme-linked immunoadsorbent assay. Results In our study, we found VEGF levels in malignant ascites （909. 16 ±583.15 pg/ml） were significantly higher than those in benign ascites （258.13± 127.82 pg/ml） （P 〈0.001）. Meanwhile, we also found that VEGF levels in malignant ascites were associated with TNM stage and lymphatic invasion. Patients with a high level of VEGF （≥613.38 pg/ml） in malignant ascitos exhibited poor moan survival rate [ （9.98± 0. 68） vs （23.64 ± 0. 65 ） months, P 〈 0. 001 ]. In a multivariate Cox regression model, higher ascites VEGF was an independent prognostic factor for overall survive. Conehtsion 31ae high level of VEGF value in malignant ascites may be used as an independent prognostic factor in patients with ovarian cancer.