摘要
The gelatin-glutaraldehyde （gelatin-GA） nanofibers were electrospun in order to overcome the defects of ex-situ crosslinking process such as complex process, destruction of fiber morphology and decrease of porosity. The morphological structure, porosity, thermal property, moisture absorption and moisture retention performance, hydrolytic resistance, mechanical property and biocompatibiUty of nanofiber scaffolds were tested and characterized. The gelatin-GA nanofiber has nice uniform diameter and more than 80% porosity. The hydrolytic resistance and mechanical property of the gelatin-GA nanofiber scaffolds are greatly improved compared with that of gelatin nanofibers. The contact angle, moisture absorption, hydrolysis resistance, thermal resistance and mechanical property of gelatin-GA nanofiber scaffolds could be adjustable by varying the gelatin solution concentration and GA content. The gelatin- GA nanofibers had excellent properties, which are expected to be an ideal scaffold for biomedical and tissue engineering applications.
The gelatin-glutaraldehyde （gelatin-GA） nanofibers were electrospun in order to overcome the defects of ex-situ crosslinking process such as complex process, destruction of fiber morphology and decrease of porosity. The morphological structure, porosity, thermal property, moisture absorption and moisture retention performance, hydrolytic resistance, mechanical property and biocompatibiUty of nanofiber scaffolds were tested and characterized. The gelatin-GA nanofiber has nice uniform diameter and more than 80% porosity. The hydrolytic resistance and mechanical property of the gelatin-GA nanofiber scaffolds are greatly improved compared with that of gelatin nanofibers. The contact angle, moisture absorption, hydrolysis resistance, thermal resistance and mechanical property of gelatin-GA nanofiber scaffolds could be adjustable by varying the gelatin solution concentration and GA content. The gelatin- GA nanofibers had excellent properties, which are expected to be an ideal scaffold for biomedical and tissue engineering applications.
基金
Acknowledgements This research was supported by the National Natural Science Foundation of China （Grant Nos. 31470941 and 31271035）, the Innovation Fund Designated for Graduate Students of Donghua University （Item No. CUSF-DH-D-2015032）, Science and Technology Commission of Shanghai Municipality （15JC1490100, 15441905100）, Ph.D. Programs Foundation of Ministry of Education of China （20130075110005） and light of textile project 0201404）, Technology Bureau of Jiaxing City （MTC2012- 006, 2011A Y1026）, Science and Technology Agency of Zhejiang Province （2012R10012-09, 2010R50012-19）. The authors would like to extend their sincere appreciation to the Deanship of Scientific Research at King Saud University for its funding of this research through the research group project No. RGP-201.
