PRDM16、TRPM8、TSPAN2及MMP16等基因多态性与无先兆偏头痛关联性研究

The Research on the Correlation between Gene Polymorphism Such as PRDM16,TRPM8,TSPAN2,MMP16etc and Migraine Without Aura

目的探讨中国西南地区汉族人群中PRDM16、TRPM8、TSPAN2及MMP16等基因多态性与无先兆偏头痛遗传易感性关系。方法共收集512例无先兆偏头痛和535例健康正常对照,运用病例-对照分析,荟萃分析目前国内外报道的全基因组关联分析(genome-wide association studies,GWAS),单碱基延伸法(SNa Pshot)进行多个基因11个SNP位点的基因分型。结果 rs2651899(PRDM16),rs10166942(TRPM8),rs12134493(TSPAN2)和rs10504861(MMP16)与无先兆偏头痛发病具相关性。结论本研究重复了以前GWAS结果,PRDM16,TRPM8,TSPAN2,MMP16基因的SNP位点与无先兆偏头痛发病相关。

Objective To study the relationship of genetic susceptibility between gene polymorphism such as PRDM16,TRPM8,TSPAN2,MMP16 and migraine without aura in the Han population in southwest China. Methods To collect 512 cases with migraine without aura and 512 cases of healthy controlsa. Using cases-contrast analysis,meta-analysis to study the genomewide association analysis reported at home and abroad（ genome- wide association studies,GWAS）. Using the single-base extension method（ SNa Pshot） to analyze the 11 SNP loci of multiple genes. Results rs2651899（ PRDM16）,rs10166942（ TRPM8）,rs12134493（ TSPAN2）,and rs10504861（ MMP16） were associated with migraine without aura. Conclusion This study repeated the GWAS results before,that SNP locus of PRDM16,TRPM8,TSPAN2,MMP16 genes was associated with the onset of migraine without aura.