哪些非酒精性脂肪性肝炎-肝癌动物模型更具实用价值？

Which animal models of nonalcoholic steatohepatitis-hepatocellular carcinoma （NASH-HCC） have more practical value in experimental investigations？

非酒精性脂肪性肝病（NAFLD）曾被认为只在进展到肝硬化后才发生肝癌,新近的临床研究表明NAFLD在脂肪性肝炎（NASH）期就可出现肝癌.NAFLD的流行及其恶变率的升高要求尽早阐明肝细胞癌（HCC）的发病机制,评估新颖治疗的效果,这需要可靠的动物模型.现总结具有实用价值的NASH-HCC模型的特点,希望利用这些模型揭开NASH-HCC的神秘面纱.

In the past,we used to think that hepatocellular carcinoma （HCC） only occurred when nonalcoholic fatty liver disease （NAFLD） progressed to liver cirrhosis.However,recent clinical studies have shown that HCC may occur during the stage of nonalcoholic steatohepatitis （NASH）.The prevalence of NAFLD and the increasing incidence of NASH-associated HCC require the elucidation of the pathogenesis of NASH-HCC and the assessment of the efficacy of novel therapies as early as possible,while these evaluations need reliable animal models.This article reviews the characteristics of NASH-HCC models with a practical value to uncover the mysteries of NASH-HCC.