平肝益肾汤联合前列地尔治疗椎-基底动脉供血不足性眩晕疗效及对患者血清内皮素-1和降钙素基因相关肽水平的影响

Efficacy of Ping-gan-yi-shen decoction in combination with Alprostadil in treatment of vertebra-basilar artery ischemic vertigo and its effects on level of ET-1 and CGRP

目的探讨平肝益肾汤联合前列地尔治疗椎-基底动脉供血不足性眩晕的临床疗效及对患者血清内皮素-1(ET-1)和降钙素基因相关肽(CGRP)水平的影响。方法选取河南中医学院第一附属医院就诊的120例椎-基底动脉供血不足性眩晕患者,并按照随机数字表法随机分为两组。对照组给予前列地尔治疗,观察组在对照组基础上联合应用平肝益肾汤治疗。评价比较组间临床疗效、椎-基底动脉血流速度及血清ET-1、CGRP水平。结果疗效评价后观察组治疗总有效率明显高于对照组(96.7%vs 86.7%,P<0.05)。观察组治疗后与对照组比较,左侧椎动脉、右侧椎动脉及基底动脉血流速度增快[(33.7±4.5)cm/s vs(28.5±4.3)cm/s,(34.3±5.6)cm/s vs(29.2±5.1)cm/s,(36.9±6.7)cm/s vs(30.5±5.8)cm/s,P<0.05],ET-1水平下降[(122.5±9.7)ng/L vs(142.3±10.6)ng/L,P<0.05],CGRP水平升高[(32.2±3.8)ng/L vs(26.9±3.4)ng/L,P<0.05]。结论平肝益肾汤联合前列地尔治疗椎-基底动脉供血不足性眩晕疗效可靠,能够显著提高临床疗效,改善椎-基底动脉供血,调节机体ET-1和CGRP水平,临床上值得应用。

Objective To investigate the efficacy of Ping-gan-yi-shen decoction in combination with Alprostadil in treatment of vertebra-basilar artery ischemic vertigo and its effects on level of endothelin-1（ET-1） and calcitonin gene-related peptide（CGRP）. Methods Patients of vertebra-basilar artery ischemic vertigo were divided into two groups equally. The control group was treated with Alprostadil,while the observation group was treated with Ping-gan-yi-shen decoction in combination with Alprostadil. Then,the curative efficacy,blood flow velocity of vertebrabasilar artery,serum ET-1 and CGRP were observed and compared. Results The total therapeutic efficacy ratio in the observation group was statistically higher than that in the control group（96.7% vs 86.7%,P〈0.05）. After the treatment,in comparison with the control group,the observation group had statistically more increased blood flow velocity of left vertebral artery,right vertebral artery and basal artery [（33.7 ± 4.5） cm/s vs（28.5 ± 4.3） cm/s,（34.3 ±5.6） cm/s vs（29.2 ± 5.1） cm/s,（36.9 ± 6.7） cm/s vs（30.5 ± 5.8） cm/s,P0.05]. And the observation group had statistically lower level of ET-1 [（122.5 ± 9.7） ng/L vs（142.3 ± 10.6） ng/L,P〈0.05] and higher level of CGRP [（32.2± 3.8） ng/L vs（26.9 ± 3.4） ng/L,P〈0.05] in comparison with the control group. Conclusions Ping-gan-yi-shen decoction in combination with Alprostadil is effective for vertebra-basilar artery ischemic vertigo,which can significantly increase curative efficacy,improve blood supply of vertebra-basilar artery and regulate level of ET-1 and CGRP.