孟鲁斯特钠联合山莨菪碱治疗小儿反复发作性过敏性紫癜的临床疗效观察

Observation on the Curative Effect of Montelukast Combined with Anisodamine for the Treatment of Repeatedly Relapsing Anaphylactoid Purpura in Children

目的探讨孟鲁司特钠联合山莨菪碱治疗小儿反复发作性过敏性紫癜的临床疗效。方法选取我院2013年4月至2015年4月收治的反复发作性过敏性紫癜患儿共54例,按照入院时间顺序随机分为对照组与观察组各27例。两组患儿均接受紫癜常规治疗包括禁食、输液、抗感染、抗过敏药物、激素治疗等,此外,对照组采用单纯孟鲁司特钠治疗,观察组采用孟鲁司特钠联合山莨菪碱治疗。治疗结束后比较两组患儿的疗效,紫癜、便血、血尿消失时间,以及尿生化指标。结果治疗后观察组治疗显效率为66.7%,显著高于对照组的33.3%,差异有统计学意义(P<0.05)。观察组患儿紫癜、便血、血尿消失时间均显著短于对照组,差异有统计学意义(P<0.05)。观察组患儿的尿生化指标显著均优于对照组(P<0.05)。结论孟鲁司特钠联合山莨菪碱治疗小儿反复发作性过敏性紫癜具有较好的临床疗效,安全可靠,值得临床应用。

Objective To explore the clinical effect of montelukast combined with anisodamine for the treatment of repeatedly relapsing anaphylactoid purpura in children. Methods A total of 54 cases of children with repeatedly relapsing anaphylactoid purpura admitted to our hospital from April 2013 to April 2015 were selected, and randomly divided into two groups equally. All patients received routine therapy; in addition, the control group received the treatment of montelukast, while the observation group received the treatment of montelukast combined with anisodamine. After treatment, the curative effect, disappearance time of purpura, hematochezia and hematuria,and the urine biochemical indicators were compared between two groups. Results The obviously effective rate of observation group was66.7%, significantly higher than 33.3% of control group（P〈0.05）. The disappearance time of purpura, hematochezia and hematuria of observation group were significantly shorter than those of control group（P〈0.05）. The urine biochemical indicators of observation group were significantly better than those of control group（P〈0.05）. Conclusions Montelukast combined with anisodamine has significant efficacy for the treatment of repeatedly relapsing anaphylactoid purpura in children.