慢性乙型肝炎患者免疫球蛋白检验的临床研究

Clinical Study of Immune Globulin Test in Patients with Chronic Hepatitis B

目的探讨慢性乙型肝炎患者免疫球蛋白检验的临床意义。方法选择120例慢性乙型肝炎患者,根据其病情分为慢性重型乙型肝炎组(A组,43例)和慢性乙型肝炎组(B组,77例),选择同期在我院进行健康体检的60例健康体检人员作为对照组,对三组进行Ig G、Ig A、Ig M等免疫球蛋白水平检测。同时根据患者病情进展情况将所有慢性乙型肝炎患者分为改善组(88例)和非改善组(32例),比较分析两组的免疫球蛋白水平、凝血酶原活动度(PTA)以及总胆红素水平(TBIL)。结果慢性乙型肝炎患者的免疫球蛋白水平显著高于对照组(P<0.05),且A组患者的免疫球蛋白水平显著高于B组患者(P<0.05)。改善组患者内的免疫球蛋白水平、TBIL显著低于非改善组患者(P<0.05),改善组患者PTA显著高于度非改善组患者(P<0.05)。结论 Ig G、Ig A、Ig M等免疫球蛋白,凝血酶原活动度(PTA)以及总胆红素水平(TBIL)可作为有效的指标诊断和判断乙型肝炎的发生和病情的进展,可以作为临床进行针对性治疗时的参考依据。

Objective To investigate the clinical significance of the immune globulin test in patients with chronic hepatitis B（CHB）.Methods A total of 120 cases of CHB patients were selected and divided into group A（43 cases, severe CHB） and group B（77 cases, CHB）according the degree of disease; 60 cases of healthy population with physical examination were selected as control group. The levels of Ig G,Ig A and Ig M of three groups were detected. All 120 cases of CHB patients were divided into the improved group（88 cases） and non-improved group（32 cases） according to the disease progression, and the immunoglobulin levels, prothrombin activity（PTA） and total bilirubin（TBIL）were compared between those two groups. Results The immunoglobulin levels of CHB patients were significantly higher than those of control group（P〈0.05）, and group A was significantly higher than group B（P〈0.05）. The immunoglobulin levels and TBIL of improved group were significantly lower than those of non-improved group（P〈0.05）, and the PTA level was significantly higher than that of non-improved group（P〈0.05）. Conclusions The immunoglobulin levels（Ig G, Ig A, Ig M）, PTA, and TBIL can be used as effective indicators for diagnose and determine the incidence and disease progression of hepatitis B, and the reference of targeted therapy in clinic.