开喉剑喷雾剂和热毒宁注射液联合治疗疱疹性咽峡炎的可行性及安全性

Feasibility and Safety of Kaihoujian Spray Combined with Reduning Injection for the Treatment of Herpangina

目的探讨开喉剑喷雾剂和热毒宁注射液联合治疗疱疹性咽峡炎的可行性及安全性。方法选取2013年12月至2015年7月我院收治的108例疱疹性咽峡炎患者作为研究对象,采用随机数字表法将所选患者分为两组各54例,对照组单独使用热毒宁注射液治疗,研究组使用开喉剑喷雾剂和热毒宁注射液联合治疗。综合比较两组患者治疗总有效率、临床症状消失时间及不良反应发生率的差异。结果研究组治疗总有效率为88.9%,高于对照组的74.1%(P<0.05);研究组咽痛、溃疡、流涎、发烧等症状消失时间均较对照组短(P<0.05);研究组和对照组的不良反应发生率分别为7.4%、5.6%,组间比较无统计学差异(P>0.05)。结论开喉剑喷雾剂和热毒宁注射液联合治疗疱疹性咽峡炎疗效突出,起效快,不良反应少,值得临床推广使用。

Objective To explore the feasibility and safety of Kaihoujian spray combined with Reduning injection for the treatment of herpangina. Methods A total of 108 cases of patients with herpangina admitted to our hospital from December 2013 to July 2015 were selected and randomly divided into two groups, with 54 cases in each group. The control group received the treatment of Reduning injection,while the study group received the combined treatment of Kaihoujian spray and Reduning injection. The differences in total effective rate,disappearance time of clinical symptoms and incidence of adverse reactions between two groups were analyzed. Results The total effective rate of study group was 88.9%, significantly higher than 74.1% of control group（P〈0.05）. The disappearance time of sore throat, ulcers,salivation and fever of study group were significantly shorter than those of control group（P〈0.05）. The incidence of adverse reactions of study group and control group were 7.4% and 5.6% respectively, with no statistical difference（P〉0.05）. Conclusions Kaihoujian spray combined with Reduning injection for the treatment of herpangina has significant efficacy, with rapid onset and few adverse reactions.