结肠癌应用完整结肠系膜切除手术治疗的效果分析

Analysis on the Effect of Complete Mesocolic Excision for the Treatment of Colon Cancer

目的研究结肠癌患者采用完整结肠系膜切除术的临床治疗效果。方法临床纳入2011年5月至2012年6月期间收治的结肠癌患者96例,按随机数字表法将患者分为两组各48例。其中对照组患者采用传统结肠癌根治术进行治疗,观察组患者采用完整结肠系膜切除术进行治疗。比较两组的治疗效果。结果观察组的出血量、住院时间以及淋巴结清扫数均优于对照组(P<0.05),而手术时间及术后排气时间与对照组比较无统计学差异(P>0.05)。观察组的总有效率为87.5%,显著高于对照组的72.9%(P<0.05)。观察组并发症发生率为4.17%,显著低于对照组的18.75%(P<0.05)。观察组1年生存率、3年生存率均显著高于对照组,局部复发率显著低于对照组(均P<0.05)。结论完整结肠系膜切除手术优于传统根治术,不仅减少了并发症的发生,提高了治疗效果,还减少了术中出血量和住院时间,增加了局部淋巴结清扫程度,使患者术后生存率更高,复发率更低,值得临床应用及推广。

Objective To explore the clinical effect of complete mesocolic excision for the treatment of colon cancer. Methods A total of 96 cases of patients with colon cancer admitted to our hospital from May 2011 to June 2012 were selected and randomly divided into two groups, with 48 cases in each group. The control group was treated with traditional radical colonectomy, while the observation group was treated with complete mesocolic excision. The effects of two groups were compared. Results The observation group was superior to the control group in the blood loss volume, length of hospital stay and number of removed lymphatic nodes（P〈0.05）, while no statistical difference was found between two groups in the operation time and postoperative exhaust time（P〉0.05）. The total effective rate of observation group was 87.5%, significantly higher than 72.9% of control group（P〈0.05）. The incidence rate of complications of observation group was 4.17%, significantly lower than 18.75% of control group（P〈0.05）. The 1-year survival rate and 3-year survival rate of observation group were significantly higher than those of control group, and the local recurrence rate was significantly lower than that of control group（P〈0.05）. Conclusions Complete mesocolic excision can reduce the incidence of complications, improve curative effect,reduce the intraoperative blood loss, shorten the length of hospital stay, increase the regional lymph node dissection, incease the postoperative survival rate, and lower the recurrence rate; It has better efficacy than traditional radical colonectomy operation.