克罗米芬与来曲唑用于多囊卵巢综合征性不孕患者促排卵效果观察

Clinical observation of Clomiphene and Letrozole in treatment of infertility patients with POCS

目的探讨克罗米芬(CC)与来曲唑(LE)用于多囊卵巢综合征(PCOS)性不孕症患者促排卵治疗的效果。方法以75例PCOS不孕症患者为研究对象,分为CC组和LE组,分别纳入病例37例和38例,观察2组促排卵的临床效果。结果 CC组平均完成4.4个(162/37)周期,LE组平均完成5.2个(198/38)周期,CC组有排卵的周期(54.9%,89/162)明显多于LE组(42.4%,84/198),差异有统计学意义(P<0.05)。CC组人绒毛膜促性腺激素(HCG)日子宫内膜厚度、成熟卵泡数和雌二醇(E2)激素水平与LE组比较差异有统计学意义(P<0.05)。CC组随访妊娠率35.1%(13/37),LE组39.4%(15/38),差异无统计学意义(P>0.05)。结论克罗米芬用于PCOS患者促排卵,平均促排卵周期少,有排卵的周期比例高,HCG日成熟卵泡数多,但是影响子宫内膜厚度和E2激素水平,治疗后临床妊娠率与来曲唑相当。

Objective To investigate the effect of using clomiphene （CC）and letrozole （LE）in treatment of infertility patients with polycystic ovary syndrome ovulation （PCOS）. Methods 75 cases of PCOS as the research object were divided to CC group and LE group with 37 cases and 38 cases, the clinical effect of ovulation induction was observed. Results In CC group, the average completed cycle was 4.4 （162/37）, LE group was 5.2 （198/38）, and o vulatory cycle （54.9%, 89/162） in CC group was significantly higher than that of the LE group （42.4%, 84/198） （P〈0.05）. The endometrial thickness, number of mature follicles and E2 hormone levels of CC group on HCG day were significantly different from that of LE group （P〈0.05）. Pregnancy rate of CC group was 35.1% （ 13/37 ）, and LE group was 39.4% （15/38） （P〉0.05）. Conclusion Using clomiphone citrate in the treatment of PCOS, the average promoting ovulation cycle is less, ovulatory cycle ratio is high, mature follicle is multiple on HCG day, however, it impacts the endometrial thickness and E2 hormone levels, the clinical pregnancy rate after treatment is roughly equivalent with letrozole.