个体化医学理念在神经外科脑胶质瘤实习教学中的应用

Implementation of personalized medicine concept in the clinical teaching of glioma surgery

目的探讨个体化医学理念在脑胶质瘤实习教学中的价值。方法将临床医学七年制学生分为实验组（40人）和对照组（40人）。实验组实施个体化医学教学，在胶质瘤临床教学中导入个体化医学的理念与方法；对照组实施常规教学。通过问卷调查及答题考核评价教学效果，分别用卡方检验及t检验作统计分析。结果课程满意度问卷显示，实验组有37名（92．5％）学生对新教学方法具有浓厚兴趣。实验组有36名（90％）学生认为能增加学习兴趣、37名（92％）学生认为能优化脑胶质瘤临床诊疗流程、34名（85％）学生认为能拓宽诊治思路、38名（95％）学生认为能增强临床思维能力、32名（80％）学生认为能增强医患沟通能力，相对对照组学生在各项目上的选择情况，差异均有统计学意义（P〈0．05）。实验组学生脑胶质瘤课程考核成绩为（88．71±6．54）分，对照组学生（76．49±7．32）分，差异具有统计学意义（P=O．000）。结论个体化医学理念的引进，有利于医学生根据各项临床资料对胶质瘤患者制定更为个体化的诊疗方案，有利于培养其临床思维能力和循证医学的观念，值得推广。

Objective To explore the value of applying personalized medicine in the clinical teaching of glioma surgery. Methods Totally 80 7-year program undergraduates were divided into experimental class and control class randomly, with 40 cases in each group. The experimental class received personalized medical teaching through introducing idea and method of personalized medicine. The control class received conventional teaching. The effect of teaching was evaluated by questionnaire and examination. The data were analyzed through Chi-square and t-test test. Result Questionnaire survey of satisfaction showed that 37 students of experimental class （92.5%） were interested in the new course. Questionnaire survey of teaching effect showed that in experimental class 36 students （90%） felt it could increase learning interest, 37 students （92%） believed it improved glioma diagnosis and treatment, 34 students （85%） felt their medical view expanded, 38 students had consolidated clinical thinking, and 32 students （80%） improved negotiation with patients. All issues were significantly better than control class （P〈0.05）. Meanwhile, statistical difference was found in average score between experiment class and control class [（88.71 ± 6.54） vs. （76.49 ± 7.32）] （P=0.000）. Conclusion The introduction of personalized medicine concept helps medical students to make personalized diagnosis and treatment plan for glioma patients, and is conducive to the cultivation of their clinical thinking ability and evidence based medicine concept, which is worthy of promotion.