期刊文献+

亚油酸氧化产物——白细胞毒素和白细胞毒素二醇的研究进展

Progress in Studies on Oxidation Products of Linoleic Acid Leukotoxin and Leukotoxin Diols
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摘要 白细胞毒素(leukotoxin,Ltx)和白细胞毒素二醇(leukotoxin diol,Ltxd)是亚油酸的氧化产物,研究表明,Ltx和Ltxd具有细胞毒性,与哺乳动物多种疾病相关,而外源性Ltx和Ltxd的摄入可以引起哺乳动物内分泌紊乱。本文系统综述Ltx和Ltxd的发现、形成机理、病理和生理学意义、毒性作用以及检测方法,并对未来的研究重点进行展望。 Leukotoxin(Ltx) and leukotoxin diol(Ltxd) are oxidation products of linoleic acid(LA). The existing studies indicate that both Ltx and Ltxd are cytotoxic and associated with a number of mammalian diseases. Exogenous Ltx and Ltxd can disrupt the endocrine function in female rats. The present paper reviews the recent progress made in the studies of Ltx and Ltxd with respect to discovery, mechanisms of formation, pathological and physiological significance, toxicological effects and analytical methods. Moreover, further studies in this area are also suggested.
出处 《食品科学》 EI CAS CSCD 北大核心 2016年第5期223-229,共7页 Food Science
基金 国家自然科学基金青年科学基金项目(31401560) 江苏省农业科技自主创新资金项目(CX(13)3081)
关键词 亚油酸 脂质氧化 白细胞毒素 白细胞毒素二醇 linoleic acid lipid oxidation leukotoxin leukotoxin diol
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  • 1SALEM N, PAWLOSKY R, WEGHER B, et al. In vivo conversion of linoleic acid to araehidonic acid in human adults[J]. Prostaglandins, Leukotrienes and Essential Fatty Acids, 1999, 60(5/6): 407-410. DOI: 10.1016/S0952-3278(99)80021-0.
  • 2MOGHADDAM M F, GRANT D F, CHEEK J M, et al. Bioactivation of leukotoxins to their toxic diols by epoxide hydrolase[J]. Nature Medicine, 1997, 3: 562-566. DOI:10.1038/nm0597-562.
  • 3LURIA A, WELDON S M, KABCENELL A K, et al. Compensatory mechanism for homeostatic blood pressure regulation in Ephx2 gene- disrupted mice[J]. Journal of Biological Chemistry, 2007, 282: 2891-2898. IX)I: 10.1074/jbe.M608057200.
  • 4MORAN J H, WEISE R, SCHNELLMANN R G, et al. Cytotoxieity of linoleie acid diols to renal proximal tubular cells[J]. Toxicology and Applied Pharmscology, 1997, 146: 53-59, DOI:10.1006/ taap.1997.8197.
  • 5SISEMORE M F, ZI-IENG J, YANG J C, et al. Cellular characterization of leukotoxin diol-induced mitochondrial dysfunction[J]. Archives of Biochemistry and Biophysics, 2001, 392(I): 32-37. DOI:I0.1006/ abbi.2001.2434.
  • 6ISHIZAKI T, SHIGEMORI K, NAKAI T, et al. Leukotoxin, 9,10-epoxy-12-octadecenoate causes edematous lung injury via activation of vascular nitric oxide synthase[J]. American Journal of Physiology, 1995, 269: L65-L70.
  • 7ISHIZAKI T, SHIGEMORI K, NAKAI T, et al. Endothelin-1 potentiates leukotoxin-induced edematous lung injury[J]. Journal of Applied Physiology, 1995, 79:1106-1111.
  • 8HU J N, TAKI F, SUGIYAMA S, et al. Neutrophilderived epoxide, 9,10-epoxy-12-octadecenoate, induces pulmonary edema[J]. Lung, 1988, 166: 327-337. DOI:10.1007/BF02714065.
  • 9SUGIYAMA S, HAYAKAWA M, NAGAI S, et al. Leukotoxin, 9,10-epoxy-12-octadecenoate, causes cardiac failure in dogs[J]. Life Science, 1987, 40:225-231. DOI: 10.1016/0024-3205(87)90336-5.
  • 10PI]SSA T, RAUDSEPP P, TOOMIK P, et al. A study of oxidation products of free polyunsaturated fatty acids in mechanically deboned meat[J]. Journal of Food Composition and Analysis, 2009, 22:307-314. DOI: 10.1016/j.j fca.2009.01.014.

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