摘要
白细胞毒素(leukotoxin,Ltx)和白细胞毒素二醇(leukotoxin diol,Ltxd)是亚油酸的氧化产物,研究表明,Ltx和Ltxd具有细胞毒性,与哺乳动物多种疾病相关,而外源性Ltx和Ltxd的摄入可以引起哺乳动物内分泌紊乱。本文系统综述Ltx和Ltxd的发现、形成机理、病理和生理学意义、毒性作用以及检测方法,并对未来的研究重点进行展望。
Leukotoxin(Ltx) and leukotoxin diol(Ltxd) are oxidation products of linoleic acid(LA). The existing studies indicate that both Ltx and Ltxd are cytotoxic and associated with a number of mammalian diseases. Exogenous Ltx and Ltxd can disrupt the endocrine function in female rats. The present paper reviews the recent progress made in the studies of Ltx and Ltxd with respect to discovery, mechanisms of formation, pathological and physiological significance, toxicological effects and analytical methods. Moreover, further studies in this area are also suggested.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2016年第5期223-229,共7页
Food Science
基金
国家自然科学基金青年科学基金项目(31401560)
江苏省农业科技自主创新资金项目(CX(13)3081)