摘要
目的探讨抑郁症患者自杀意念与事件相关电位的相关性。方法选取100例抑郁症患者,其中伴自杀意念患者50例(有自杀意念抑郁组),不伴自杀意念患者50例(无自杀意念抑郁组)及健康对照者50名(对照组),抑郁症患者进行汉密尔顿抑郁量表(HAMD)评定,对全部入组样本测定事件相关电位。结果有自杀意念抑郁组P300潜伏期长于无自杀意念抑郁组(P<0.05),有自杀意念抑郁组P300波幅短于无自杀意念抑郁组(P<0.05)。有自杀意念抑郁组与无自杀意念抑郁组患者P300潜伏期长于对照组,P300波幅短于对照组(P<0.05)。有自杀意念抑郁组与无自杀意念抑郁组P300波幅均与HAMD绝望感因子分呈负相关(P<0.05)。结论抑郁症患者存在明显认知功能损害,其自杀意念与认知功能损害有关。
Objective To explore the relationship between suicidal ideation and event related potential in patients with depression. Methods A total of 50 depressive patients with suicidal ideation in depression with suicidal ideation group,50 depressive patients without suicidal ideation in depression without suicidal ideation group and 50 healthy people in control group were selected in this study. The depressive patients were assessed with Hamilton Depression Scale（ HAMD） and all subjects were examined with the event related potential. Results The latency of P300 in depression with suicidal ideation group was significantly longer than that in depression without suicidal ideation group（ P〈0. 05）,and the amplitude of P300 in depression with suicidal ideation group was significantly shorter than that in depression without suicidal ideation group（ P〈0. 05）. The latencies of P300 in depressive patients were significantly longer than that in control group（ P〈0. 05）,and the amplitudes of P300 in depressive patients were significantly shorter than that in control（ P〈0. 05）. The amplitudes of P300 were negatively related to the desperation factor scores of HAMD in depressive patients（ P〈0. 05）. Conclusion There is obvious impairment of cognitive function in the patients with depression,which is related to the suicidal ideation of the patients.
出处
《精神医学杂志》
2016年第1期32-34,共3页
Journal of Psychiatry
