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巨噬细胞TLR2介导的老年人抗结核免疫研究进展 被引量：4

The role of immunity mediated by TLR2 in macrophages against tuberculosis in elderly adults
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摘要 巨噬细胞是重要的固有免疫细胞，也是结核分枝杆菌侵犯的主要靶细胞。巨噬细胞可表达多种Toll样受体，其中TLR2是巨噬细胞识别结核分枝杆菌的结构成分，激活TLR2信号通路可以启动细胞内信号转导，诱导特异性基因表达，分泌细胞因子从而发挥效应。老年人免疫功能衰退，巨噬细胞的功能也发生了改变。本文就巨噬细胞TLR2介导的老年人抗结核免疫的相关研究进展进行综述。 Objective Macrophages are important innate immune cells, and are also the main target cells of Mycobacterium tuberculosis. Macrophages express many kinds of Toll like receptors. TLR2 is a structural component of macrophages in the identification of Mycobacterium tuberculosis. Activation of TLR2 signaling pathway can activate cell signal transduction, induce specific gene expression and secretion of cytokines. Immune function decline in old people and the function of macrophages was also changed. In this article, The role of immunity mediated by TLR2 in macrophages against tuberculosis in the elderly is reviewed.
作者 姜泓 王丽梅
机构地区 第四军医大学唐都医院老年病科 第四军医大学微生物学与病原生物学教研室
出处 《中华老年医学杂志》 CAS CSCD 北大核心 2016年第3期338-341,共4页 Chinese Journal of Geriatrics
关键词 结核 巨噬细胞 TOLL样受体 Tuberculosis Mcrophages Toll like receptors
分类号 R52 [医药卫生—内科学]
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参考文献30

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共引文献21

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引证文献4

二级引证文献13

中华老年医学杂志
2016年 第3期

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