埃索美拉唑与奥美拉唑治疗十二指肠溃疡疗效比较

Comparative study of Esomeprazole versus Omemeprazole in patients with duodenal ulcer

目的评估埃索美拉唑治疗十二指肠溃疡(duodenal ulcer,DU)的临床疗效和安全性。方法 70例DU患者,分别用埃索美拉唑片剂40 mg,qd和奥美拉唑胶囊40 mg,qd进行治疗,胃镜观察溃疡愈合程度。结果4周后埃索美拉唑组和奥美拉唑组溃疡愈合率分别为91.4%和88.6%,总有效率分别为97.1%和94.2%。但埃索美拉唑比奥美拉唑缓解DU疼痛更为快速,埃索美拉唑组1 d内的疼痛消失率为42.9%,而奥美拉唑组为14.3%。结论埃索美拉唑治疗DU具有较好的疗效,且无明显不良反应,值得临床推广。

Objective To evaluate the effect and safety of esomeprazole in patients with duodenal ulcer. Methods70 patients with duodenal ulcerwere randomly assigned to receive one of the two regimens.they were esomeprazole（S-OPZ）40mg oral qd and omemeprazole（OPZ）40mg qd.Endoscopies and routine lboratory tests were performed before the rial and within 3 days after the rial to assess therapeutic efficacy. Results After 4weeks of treatment,the ulcer-healing rate achived91.4% of S-OPZ patients and 88.6% of OPZ patients,the general effective rate achived97.1% and 94.2%recpectively in both groups.The trial results showed that the pain rilief rate within first 0ne day after the treatment in S-OPZ group and OPZ group was 42.9% and 14.3% respectively.It appears that S-OPZ is quicker in relieving the ulcer pain than OPZ. Conclusions The result suggests that S-OPZis a very effective and well-tolerated proton pump inhibitors and it is worthy to be recommended for administration in patients with duodenal ulcer.