高血压患者昼夜血压节律与血清尿酸的相关性

The correlation of uric acid level and the circadian rhythm of blood pressure in hypertensive patients

目的探讨高血压患者昼夜血压节律变化与血清尿酸水平的相关性。方法选择年龄及性别构成相匹配非杓型高血压患者70例（非杓型高血压组）、杓型高血压患者70例（杓型高血压组）及健康对照者52例（对照组）。记录并比较三组临床资料及血液生化指标，采用多元Logistic回归分析影响昼夜血压节律变化的危险因素。结果非杓型高血压组尿酸水平最高[（393．57±53．52）μmol／L]，杓型高血压组次之[（280．57±41．64）μmol/L]，对照组尿酸水平最低[（267．66±59．38）μmol/L]，两两比较差异均有统计学意义（P〈0．01）。多因素Logistic回归分析显示，尿酸水平是高血压患者发生非杓型昼夜血压节律的独立预测因素（P=0．003，OR=2．26，95％CI：1．34—3．89）。结论高尿酸水平可能是导致高血压患者出现非杓型血压节律的危险因素。

Objective To investigate the correlation of uric acid（UA） level and the circadian rhythm of blood pressure in hypertensive patients. Methods Among the individuals who presented to the cardiology clinic, 70 patients who had hypertension and were diagnozed with non-dipper hypertension （non-dipper hypertension group） by 24 h ambulatory blood pressure monitoring （ABPM）, 70 patients with dipper hypertension patients （dipper hypertension group）, and 52 normotensive individuals （control group） were enrolled in this study. Peripheral venous blood samples were collected from all the patients in order to evaluate the hematological and biochemical parameters. All the assessed parameters were compared among three groups. Results The level of UA in non-dipper hypertension group was the highest, in dipper hypertension group was higher and in contrl group was the lowerst： （393.57±53.52）, （280.57 ± 41.64）, （267.66 ±59.38） μmol/L, and there were significant differences （P〈0.01）. Multivariate Logistic regression analysis revealed that the level of UA was an independent risk factor for non-dipper circadian rhythm of blood pressure （P = 0.003, OR = 2.26, 95% CI： 1.34- 3.89）.Conclusions The higher level of UA may be a risk factor for non-dipper circadian rhythm of blood pressure in hypertension patients.