重度烧伤患者血清胃泌素水平与应激性溃疡的关系研究

Relationship between serum gastrin level and stress ulcer in severe burns patients

[目的]探讨重度烧伤患者血清胃泌素（GAS）水平与应激性溃疡的关系。[方法]选取2011年6月~2014年10月来我院就诊的70例重度烧伤患者,分为非溃疡组（34例）和溃疡组（36例）,所有患者均于伤后不同时间检测血清GAS表达水平以及APACHEⅡ评分,并比较不同烧伤面积患者之间血清GAS表达水平。[结果]溃疡组患者不同时间血清GAS水平均显著低于非溃疡组（P〈0.01）;烧伤患者在2h后胃泌素水平降低,2~12h胃泌素水平持续处于降低状态,13~24h出现高峰,24h后降低,48h后维持相对稳定水平;不同烧伤面积患者血清GAS水平比较,差异具有统计学意义（P〈0.05）;不同程度APACHEⅡ评分患者血清GAS水平比较,差异具有统计学意义（P〈0.05）,且APACHEⅡ评分与GAS水平之间呈正相关（P〈0.05）。[结论]重度烧伤患者应激性溃疡与血清胃泌素相关,GAS水平与患者烧伤程度存在一定关系,患者烧伤后随时间延长,血清GAS水平呈现一定规律性。

[Objective]To explore the relation between serum gastrin levels（GAS）and stress ulcer in severe burn patients.[Methods]A total of 70 cases of severe burn patients from June 2011 to October 2014 in our hospital were selected.They were divided into non-ulcer group（34cases）and ulcer group（36cases）.The GAS level and APACHEⅡ scores were detected after injury at different time points.The GAS levels of patients with different burn area were compared and analyzed.[Results]The GAS levels of ulcer patients at different time points were significantly lower than the non-ulcer group（P0.01）.GAS level reduced after 2h,and continued to decrease during 2to 12 h.After 13 to 24h,GAS level reached a peak and then decreased after 24 h,which remained relatively stable after 48 h.Comparison of GAS in different burn area and different APACHEⅡscores,the difference was statistically significant（F =32.5661,P0.05）.There was a positive correlation between（P0.05）,APACHEⅡ score and GAS levels（r=0.796,P0.05）.[Conclusion]It shows that stress ulcers associate with serum gastrin in patients with severe burns.There is a certain relationship between GAS and burn degree,and serum GAS shows certain regularity with time extending.