白细胞介素10、孕酮与自然流产的相关性探讨

Study on the association between Interleukin 10 and spontaneous abortion

目的:探讨白细胞介素10(IL-10)在先兆流产发生和发展中的作用,及其与孕酮(P)的相关性,为防止自然流产的发生提供一定的理论依据。方法:采用酶联免疫吸附试验(ELISA)检测64例先兆流产患者(先兆流产组)、30例正常早期妊娠妇女(正常对照组),以及64例先兆流产中保胎治疗后成功45例(保胎成功组)、保胎治疗失败16例(难免流产组)血清P和IL-10水平。结果:先兆流产组血清P、IL-10水平均低于正常对照组(P<0.01);保胎成功组的血清P、IL-10水平均高于难免流产组(P<0.01),与正常对照组比较均无差异(P>0.05);难免流产组血清P、IL-10水平均低于正常对照组(P<0.01)。先兆流产组血清P与IL-10呈显著相关性(r=0.960,P<0.01)。结论:早期先兆流产患者存在血清P、IL-10水平异常;血清P、IL-10水平可作为判断先兆流产预后的参考指标;P与IL-10可能共同参与先兆流产的发生。

Objective：In order to provide theoretical evidence for the prevention of spontaneous abortion,this study had investigate the role of interleukin 10（IL 10）in the occurrence and development of threatened abortion and it was correlation with progesterone.Methods：Enzyme linked immunosorbent assay（ELISA）was used to detect the levels of progesterone and IL 10 in 64patients with threatened abortion（threatened abortion group）,30 patients with normal early pregnancy（normal control group）,45 patients who maintaining pregnancy（maintaining pregnancy group）,and 16 patients who failed keeping pregnancy（inevitable abortion group）.Results：The level of progesterone and IL 10 in serum of patients in threatened abortion group were significantly lower than that of the normal control group（PM0.01）.The level of progesterone and IL 10 in serum of patients in maintaining pregnancy group was significantly higher than that of inevitable abortion group（PM0.01）,but there was no significantly different when compared to patients in normal control group（P〉0.05）.The level of progesterone and IL 10 in inevitable abortion group was significantly lower than that of the normal control group（P〈0.01）.In treatment group,the level of progesterone in serum of patients had highly significant positive correlation with IL10（r = 0.960,P〈0.01）.Conclusion：The level of progesterone and IL10 in serum of early pregnent patients with threatened abortion was abnormal.The level of progesterone and IL 10 in serum could be used as a reference indicator to judge the prognosis of patients threatened abortion.Progesterone and IL10 maybe contribute to the occur of threatened abortion together.