健康青年人群颌面部温度定量感觉测试的一致性研究

Consistency of quantitative sensory testing of maxillofacial temperature in healthy young subjects

目的：探讨健康青年人群颌面部温度定量感觉的可重复性,以及不同部位、性别之间的差异。方法 ：采用温度定量感觉测试对26例受试者（男12例、女14例）左、右侧咬肌区及左侧手背部表面皮肤进行检查,测试冷感觉阈值（cold detection thresholds,CDT）、热感觉阈值（warm detection thresholds,WDT）、冷痛觉阈值（cold pain thresholds,CPT）、热痛觉阈值（hot pain thresholds,HPT）,每个部位重复测试3次,每次间隔10 min;每次给予3个刺激,每个刺激间隔4 s;1周后重复相同的测试,应用组内相关系数（intraclass correlation coefficient,ICC）评价不同时间间隔感觉阈值的重复性,重复性测试的方差分析比较不同的性别、受试部位及时间间隔对感觉阈值的影响。结果：3个测试周期的温度阈值均显示了良好的一致性（ICCCDT：0.642~0.869,ICCWDT：0.591~0.723,ICCCPT：0.672~0.967,ICCHPT：0.757~0.917）;间隔1周时间的阈值也显示良好的一致性（ICCCDT：0.508~0.772,ICCWDT：0.560~0.885,ICCCPT：0.629~0.872,ICCHPT：0.581~0.662）。左右侧面部的感觉没有明显差异（PCDT=0.398,PWDT=0.223,PCPT=0.264,PHPT=0.943）;面部较左手背部皮肤对痛觉温度刺激敏感（PCPT=0.003,PHPT=0.004）;女性较男性对痛觉温度刺激敏感（PCPT=0.008,PHPT=0.016）。结论 ：温度定量感觉测试具有较好的可重复性,可以用于颌面部体表感觉的测量;面部较左手背部皮肤对痛觉温度刺激敏感;女性较男性对痛觉温度刺激敏感。

Objective： To investigate new aspects of the test-retest reliability of thermal quantitative sensory testing（QST）maxillofacial temperature in healthy young subjects, and differences between different parts and genders. Methods： Twenty-six healthy volunteers（14 women and 12 men） participated. Cold detection threshold（CDT）, warm detection threshold（WDT）, cold pain threshold（CPT） and heat pain threshold（HPT） were measured at three sites： the surface of left hand, and the left and right masseter.The testing was performed 3 times at 10 minutes intervals with each time of 3 stimulations at 4 seconds intervals, and repeated one week later. Data were analyzed with intraclass correlation coefficients（ICC） and four-way ANOVA for repeated measures of different genders, parts and time intervals. Results： Most variables showed acceptable to excellent reliability and non-significant difference across different test cycles（ICCCDT：0.642 ~0.869, ICCWDT：0.591 ~0.723, ICCCPT：0.672 ~0.967 and ICCHPT：0.757 ~0.917）, and oneweek intervals（ICCCDT： 0.508 ~0.772, ICCWDT： 0.560 ~0.885, ICCCPT： 0.629 ~0.872, and ICCHPT： 0.581 ~0.662）. Bilateral contrastshowed no statistical significance（PCDT=0.398, PWDT=0.223, PCPT=0.264 and PHPT=0.943）. The CPT and HPT at the left hand were lower（lower sensitivity） than at the masseter（PCPT=0.003, PHPT=0.004）. There were significant gender differences with higher sensitivity in women（PCPT=0.008 and PHPT=0.016）. Conclusion： The reliability of most thermal threshold measures was acceptable for assessing somatosensory function. Facial skin is more sensitive to temperature-stimulated pain than the back of left hand skin, and female is more sensitive to temperature-stimulated pain than male.