自鼓室注射曲安奈德与盐酸氨溴索联合剂对分泌性中耳炎患者的疗效观察

lntratympanic injection of triamcinolone acetonide and ambroxonol hydrochloride in treatment of patients with secretory otitis media

目的探讨自鼓室注射曲安奈德与盐酸氨溴索联合剂对分泌性中耳炎患者临床疗效。方法收集我院2014年10月至2015年7月入院的100例分泌性中耳炎患者，随机分为两组。对照组患者给予曲安奈德治疗，实验组患者加用盐酸氨溴索治疗，比较两组患者治疗总有效率、治疗前后鼓室压与语频气导听阈、治疗后不同频率气导听力与咽鼓管功能正常人数。结果实验组患者治疗总有效率（100．0％）明显高于对照组（86．O％），差异具有统计学意义（P〈0．05）；实验组患者治疗后鼓室压（-86．38±8．45）与语频气导听阈（49．43±9．69）显著高于对照组【（-99．58±12．39）、（39．57±9．73）】，差异具有统计学意义（P〈0．01）；实验组患者在0．5kHz（9．48±2．01）、1．0kHz（6．48±2．31）与2．0kHz（4．41±1．25）下气导听力显著优于对照组【（18．24±7．56）、（14．44±5．28）、（11．29±4．36）]，差异具有统计学意义（P〈0．01）；实验组患者咽鼓管功能恢复正常发生率（86．0％）明显高于对照组（68．0％），差异具有统计学意义（P〈0．05）。结论自鼓室注射曲安奈德与盐酸氨溴索联合剂对分泌性中耳炎患者临床疗效显著，具有借鉴性。

Objective To explore the clinical curative effect of intratympanic injection of triamcinolone acetonide and ambroxonol hydrochloride in the treatment of patients with secretory otitis media. Methods 100 patients with secretory otitis media admitted into our hospital from October, 2014 to July, 2015 were collected and randomly divided into a control group and an experimental group. The control group was treated with triamcinolone acetonide and the experimental group with triamcinolone acetonide and ambroxonol hydrochloride. The total effficacy, the tympanic pressure and hearing threshold of air conductive phonetic frequency before and after the treatment, the number of people with normal hearing ability of different frequency air conduction and normal auditory tube function were compared between these two groups. Results The total efficacy of the experimental group was significantly higher than that of the control group（100% vs. 86%）, with a statistical difference （P〈0.05）. After the treatment, the tympanic pressure and hearing threshold of air conductive phonetic frequency of the experimental group were significantly better than those of the control group[（-86.38±8.45） vs. （-99.58±12.39） and （49.43±9.69） vs. （39.57±9.73）], with statistical differences （P〈0.01）. The experimental group＇s air-conduction bearing at 0.5 kHz, 1.0 kHzand 2.0 kHzwas significantly better than those of the control group[（9.48±2.01） vs. （18.24±7.56）, （6.48±2.31） vs. （14.44±5.28）, and （4.41±1.25） vs. （11.29±4.36）], with statistical differences （P〈0.01）. The rate of auditory tube function returning to normal was 86% in the experimental group and was 68% in the control group, with a statistical difference （P〈0.05） Conclusions The intratympanic injection of triamcinolone acetonide and ambroxonol hydrochloride for secretory otitis media is clinical effective and is of clinical reference.